Abstract
We evaluated a prospective cohort of 150 patients under observation in our centre for lacunar strokes. The purpose of this study was to evaluate the outcome at time of discharge and 6 months after lacunar stroke, as well as the correlation with cardiovascular risk factors and selected biochemical parameters already evaluated on admission. Focus was to identify possible prognostic factors, which might be targeted through appropriate intervention concentrating on reduction in the incidence and impact of early clinical deterioration. 150 patients with a lacunar stroke were included in the present study. A clinical 6-month follow-up was available for 98.7% of the patients. Infarcts were classified by size, shape and location. The most important predictors of high NIHSS score at time of discharge resulted NIHSS on admission (P < .001), leukocytosis (P = .013), in-hospital infections (P = .016) and size of lacunae (P = .005). Similarly, the most important predictors of poor outcome 6 months later were NIHSS on admission (P = .01), leukocytosis (P = .014), elevated CRP (P = .019), in addition to pre-admission Rankin (P < .001). Although infections are not causatively related to lacunar strokes, their prompt recognition and early treat...Continue Reading
References
Aug 1, 1987·AJR. American Journal of Roentgenology·F FazekasR A Zimmerman
Jan 28, 1999·Neurology·K NakamuraM Fujishima
Sep 6, 2001·Stroke; a Journal of Cerebral Circulation·J SerenaA Dávalos
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·Mar CastellanosAntoni Dávalos
Feb 28, 2004·European Neurology·Heinrich J AudebertRoman L Haberl
Jan 25, 2006·European Neurology·Young Seo KimSeung Hyun Kim
Jul 19, 2008·Stroke; a Journal of Cerebral Circulation·Ewoud J van DijkMonique M B Breteler
Oct 20, 2009·Journal of the Neurological Sciences·Yasumasa YamamotoKotaro Ozasa
Nov 2, 2011·Neurology·G SaposnikUNKNOWN Stroke Outcome Research Canada (SORCan) Working Group
Apr 3, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Alessandra Del BeneDomenico Inzitari
Sep 7, 2013·Stroke; a Journal of Cerebral Circulation·Alessandra Del BeneJoanna M Wardlaw
Feb 14, 2014·Stroke; a Journal of Cerebral Circulation·Mitchell S V ElkindUNKNOWN LIMITS Investigators
Oct 3, 2014·Cerebrovascular Diseases Extra·Naoki SajiKazumi Kimura
Nov 6, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lidia Garcia-BonillaCostantino Iadecola
Dec 4, 2015·Internal Medicine·Yong-Peng Yu, Lan Tan
Feb 19, 2016·Stroke; a Journal of Cerebral Circulation·Amelia K BoehmeMitchell S V Elkind
Oct 21, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Alejandro BustamanteJoan Montaner
Oct 5, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Maurizio Paciaroni, Leonardo Pantoni
Feb 10, 2018·Frontiers in Immunology·Ying Fu, Yaping Yan
Citations
Jul 20, 2019·Brain Injury : [BI]·Candice Simões Pimenta de MedeirosAíla Maria da Silva Bezerra
Jan 30, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A BerberichP Ringleb
Aug 14, 2021·Contrast Media & Molecular Imaging·Lihong HanLan Zhang