Outcome measures of facial nerve regeneration: A review of murine model systems

Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft
Miranda A ChaconJonathan I Leckenby

Abstract

Animal models of nerve function have been subject to extensive study in order to understand and investigate methods which may improve axon regeneration and promote functional outcomes following nerve injury and repair. As the facial nerve is a cranial nerve, there is mounting evidence that cranial nerve regeneration differs from peripheral, and outcome models specifically addressing the facial nerve are required. Murine models are the most commonly utilized, with a variety of methods employed to measure the actions of whisking, eye closure, or ear movement as indicators of facial nerve regeneration. Each method of measurement is reviewed in terms of validity, strengths, limitations, and the specific outcome data provided. The authors propose that prior to choosing an outcome model, the goals and objectives of a planned study should be well defined, as various outcome measures may be useful depending on the information which is desired. The aim of this paper, therefore, is to provide the reader with a concise review which may facilitate project design.

Citations

Aug 17, 2020·Current Opinion in Otolaryngology & Head and Neck Surgery·Li Gao, Takayuki Nakagawa
Feb 27, 2021·Tissue Engineering. Part B, Reviews·Fuat Baris BengurKacey G Marra
Apr 25, 2021·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Sebastian SengerJoachim Oertel
Jun 3, 2021·Regenerative Medicine·Scott R EchternachtJonathan I Leckenby
Dec 12, 2020·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Manzhi Wong, Akihiko Takushima

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