Outcome of Alcohol Septal Ablation in Mildly Symptomatic Patients With Hypertrophic Obstructive Cardiomyopathy: A Long-Term Follow-Up Study Based on the Euro-Alcohol Septal Ablation Registry

Journal of the American Heart Association
Josef VeselkaMorten K Jensen

Abstract

The long-term efficacy and safety of alcohol septal ablation (ASA) in patients with highly symptomatic hypertrophic obstructive cardiomyopathy has been demonstrated. The aim of this study was to evaluate the long-term outcomes of mildly symptomatic patients with hypertrophic obstructive cardiomyopathy treated with ASA. We retrospectively evaluated consecutive patients enrolled in the Euro-ASA registry (1427 patients) and identified 161 patients (53±13 years; 27% women) who were mildly symptomatic (New York Heart Association [NYHA] class II) pre-ASA. The median (interquartile range) follow-up was 4.8 (1.7-8.5) years. The clinical outcome was assessed and compared with the age- and sex-matched general population. The 30-day mortality after ASA was 0.6% and the annual all-cause mortality rate was 1.7%, which was similar to the age- and sex-matched general population (P=0.62). A total of 141 (88%) patients had resting left ventricular outflow tract gradient at the last clinical checkup ≤30 mm Hg. Obstruction was reduced from 63±32 to 15±19 mm Hg (P<0.01), and the mean NYHA class decreased from 2.0±0 to 1.3±0.1 (P<0.01); 69%, 29%, and 2% of patients were in NYHA class I, II, and III at the last clinical checkup, respectively. Mildly...Continue Reading

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Citations

Feb 14, 2018·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Carlos A MestresEduard Quintana
Aug 16, 2018·The New England Journal of Medicine·Barry J Maron
May 18, 2017·Journal of the American Heart Association·Brandon M JonesSamir R Kapadia
Oct 12, 2018·European Heart Journal. Quality of Care & Clinical Outcomes·Morten Kvistholm JensenJosef Veselka
Feb 13, 2018·Current Cardiology Reports·Mitsunobu KitamuraChristian Frerker
Jul 12, 2020·Journal of Cardiac Surgery·Sugeevan Savarimuthu, Amer Harky
Mar 13, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Francesco PellicciaPaolo Calabrò
Mar 19, 2020·Herz·Angelika Batzner, Hubert Seggewiß
Oct 13, 2020·Current Opinion in Cardiology·Nadia Chaudhry-Waterman, Mitchell I Cohen
Jun 3, 2021·Journal of Clinical Medicine·Victor ArévalosAnder Regueiro

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