Outcome of antibiotic prophylaxis discontinuation in patients with persistent vesicoureteral reflux initially presenting with febrile urinary tract infection: time to event analysis

The Journal of Urology
Bruno LeslieArmando J Lorenzo

Abstract

The use of antibiotic prophylaxis for preventing urinary tract infections has recently been called into question. Some studies support discontinuation of antibiotic prophylaxis in selected groups of children with vesicoureteral reflux. We report on the outcome of this practice in a cohort of patients assembled based on initial presentation with a febrile urinary tract infection. We retrospectively reviewed records of patients with persistent vesicoureteral reflux without symptoms suggestive of dysfunctional elimination who discontinued antibiotic prophylaxis after being toilet trained. Exclusion criteria consisted of secondary reflux and previous surgery for vesicoureteral reflux. End points included development of febrile urinary tract infections, renal abnormalities on followup ultrasound and need for further interventions. Infection-free survival was analyzed using the Kaplan-Meier method and compared using the log rank and Cox's tests. We evaluated 84 girls and 26 boys with a mean age of 5.4 years. Febrile urinary tract infections developed in 10 girls and 1 boy at an average of 17.2 months after discontinuation of antibiotic prophylaxis. In a time to event analysis group comparison showed no significant differences when pa...Continue Reading

References

Feb 15, 2001·Archives of Pediatrics & Adolescent Medicine·R Bachur, M B Harper
Sep 8, 2001·The Journal of Urology·R H ThompsonG F Steinhardt
Jan 5, 2005·Annals of Internal Medicine·Delia ScholesWalter E Stamm
Sep 9, 2005·The Journal of Urology·Ahmed J Al-SayyadMichael P Leonard
Sep 9, 2005·The Journal of Urology·Valeria SolariPrem Puri
Nov 26, 2005·Scandinavian Journal of Infectious Diseases·H Georgaki-AngelakiV P Syriopoulou
Jul 25, 2006·Pediatric Radiology·Richard S LeeJeanne S Chow
Apr 20, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Manish D SinhaMalcolm A Lewis
Jul 12, 2007·JAMA : the Journal of the American Medical Association·Patrick H ConwayRon Keren
Jul 20, 2007·The Cochrane Database of Systematic Reviews·E M HodsonJ C Craig
Dec 14, 2007·The Journal of Urology·Saul P GreenfieldTej Mattoo
Mar 5, 2008·The Pediatric Infectious Disease Journal·Nader ShaikhMax H Farrell
Mar 18, 2008·The Journal of Urology·Craig A Peters
Apr 16, 2008·BJU International·Jean G Hollowell
Feb 13, 2009·Journal of Paediatrics and Child Health·Premala SureshkumarJonathan C Craig
Apr 4, 2009·Advances in Urology·Hans G Pohl, A Barry Belman
Apr 14, 2009·Journal of Pediatric Urology·Laura F AlconcherLisandro A Piaggio
Jun 18, 2009·Current Opinion in Infectious Diseases·Gabrielle Williams, Jonathan C Craig
Aug 12, 2009·Nature Reviews. Urology·Christopher S Cooper
Aug 18, 2009·The Journal of Urology·Christopher S Cooper
Oct 30, 2009·The New England Journal of Medicine·Jonathan C CraigUNKNOWN Prevention of Recurrent Urinary Tract Infection in Children with Vesicoureteric Reflux and Normal Renal Tracts (PRIVENT) Inv
Oct 30, 2009·The New England Journal of Medicine·Alejandro Hoberman, Ron Keren

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Citations

Apr 11, 2013·Nephro-urology Monthly·Christopher S Cooper
Dec 3, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gregory Tasian, Susan Furth
Jun 13, 2015·The Journal of Urology·Guy HidasAntoine E Khoury
Aug 4, 2012·Pediatric Clinics of North America·Fernando F FonsecaHiep T Nguyen
Sep 25, 2017·The Journal of Urology·Michael Garcia-RoigAndrew J Kirsch
Dec 21, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Kazuyoshi JohninAkihiro Kawauchi
Jan 24, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Armando J LorenzoJoana Dos Santos
Mar 1, 2013·Arab Journal of Urology·Guy HidasAntoine E Khoury
Apr 3, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Hideshi MiyakitaMasayuki Kubota
Jun 10, 2011·Current Opinion in Urology

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