PMID: 9427893Jan 15, 1998Paper

Outcome of chickenpox in 66 pediatric renal transplant recipients

The Journal of Pediatrics
C E KashtanT E Nevins

Abstract

Although chickenpox can cause severe morbidity and mortality in pediatric renal transplant recipients, published reports describing treatment of these patients are few, especially in the cyclosporine era. Sixty-nine episodes of chickenpox occurring in 66 patients were diagnosed in our transplant population between January 1984 and May 1996. Immunosuppression consisted of prednisone and azathioprine (30 cases); prednisone, azathioprine, and cyclosporine (38 cases); or prednisone alone (1 case). Azathioprine was temporarily discontinued in 66 of 68 cases. Cyclosporine was continued at the preexisting dose in 36 of 38 cases. Acyclovir was administered parenterally in 62 of 69 cases. Sixty-five of 66 patients survived. Cyclosporine use did not increase the incidence of severe disease (p > 0.1). Acute allograft rejection occurred in three patients and responded to prednisone. Chickenpox in children with renal transplants can be successfully treated with intravenous acyclovir and temporary withdrawal of azathioprine. Allograft rejection is uncommon with this approach. Patients receiving cyclosporine do not appear to experience increased morbidity or mortality with chickenpox.

References

Feb 1, 1988·The Journal of Infectious Diseases·G NyergesS Kerpel-Fronius
Jan 1, 1981·The Journal of Pediatrics·C M FeldhoffS M Mauer
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Citations

Nov 16, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Martina PrelogLothar Bernd Zimmerhackl
Mar 25, 2005·Pediatric Transplantation·Alicia M Neu
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S A PergamUNKNOWN AST Infectious Diseases Community of Practice
Sep 24, 2005·Pediatric Transplantation·Andrew L Campbell, Betsy C Herold
Nov 30, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Josh LevitskyAlison Freifeld
Jun 5, 2019·Clinical Transplantation·Steven A PergamUNKNOWN AST Infectious Diseases Community of Practice
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·N Singh, S Husain
Jul 29, 2003·Journal of Pediatric Gastroenterology and Nutrition·Susan J Pacini-EdelsteinSue V McDiarmid
May 10, 2002·Pediatric Transplantation·Susan L Furth, Barbara A Fivush
Mar 22, 2001·Pediatric Transplantation·A D OlsonJ T Flynn
Mar 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S R SmithA Greenberg

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