May 29, 2003

Outcome of children requiring admission to an intensive care unit after bone marrow transplantation

Critical Care Medicine
Stephen J JacobeQuen Mok

Abstract

To review the outcome of bone marrow transplant (BMT) recipients admitted to a pediatric intensive care unit (ICU) and attempt to identify admission characteristics that might accurately predict a poor outcome. Retrospective case-note review. Pediatric ICU of a tertiary teaching hospital. A total of 40 BMT recipients, accounting for 57 admissions to the ICU, in the 5 yrs between 1994 and 1998 were identified. Median time to ICU admission after BMT was 42 days. Of the 40 patients admitted to ICU, 11 (22.5%) are still alive, with a median time of follow-up since their most recent ICU admission of 587 days (absolute range, 308-1803 days). A total of 32 of 57 admissions (56.1%) resulted in the patient's discharge from the ICU, and 21 admissions (36.8%) resulted in survival to at least 30 days after discharge. There was no difference between the survivors and nonsurvivors in terms of underlying diagnoses, age at BMT, or time to ICU admission after BMT. Type of BMT, conditioning regimen, and presence of significant graft vs. host disease was not found to influence outcome. Although patients who died in the ICU had a significantly longer length of stay compared with the survivors (median, 7.9 days, vs. 2.1 days, p =.02), 11 of 21 admi...Continue Reading

  • References62
  • Citations26

References

  • References62
  • Citations26

Citations

Mentioned in this Paper

Hospitals, Pediatric
Pediatric Intensive Care Unit
Voluntary Admission
Action Research
Infectious Disease of Lung
Graft-vs-Host Disease
Bone Marrow
Survival Analysis
Hospital Mortality
Respiratory Failure

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Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

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