Outcome of children with B cell lymphoma in Venezuela with the LMB-89 protocol

Pediatric Blood & Cancer
G AcquatellaA Nouel

Abstract

We analyzed the results of the LMB-89 protocol performed in seven centers in Venezuela in 96 children having B-cell non-Hodgkin lymphoma treated from 1995 to 2002. Mean age was 7.1 years with 71 (74%) been male. Eighty-two patients (85%) had diffuse small cell lymphoma Burkitt and Burkitt-like, and 14 (15%) had diffuse large B-cell lymphoma. Initial disease sites included the abdomen in 67%, peripheral nodes in 8%, and mediastinal in 4%. Treatment was directed to risk groups as described for LMB-89 protocol. Group A: seven patients (7%), group B: 80 patients (83%), and group C: nine patients (9%). Mean follow-up was 35 +/- 31 months. Complete remission (CR) occurred in 70 patients (73%); four patients (6%) had relapse during the first year and ten patients (10%) had progressive disease. Overall survival (OS) and event free survival (EFS) were 85 and 80% at 1 year, and 82 and 75% at 2 years, respectively. The EFS by therapeutic groups at 3 years was A: 100%; B: 76%, and C: 56%. neutropenia in 75%, thrombocytopenia in 63%, febrile neutropenia in 39%. Viral infections: hepatitis B in 20%, hepatitis C in 2%, and Herpes zoster in 3%. Tumor lysis syndrome (TLS) occurred in 9% during induction phase with a high mortality of 44% (urate...Continue Reading

References

Mar 1, 1995·Pediatric Hematology and Oncology·S BerberoğluI Ilhan
Aug 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R E HutchisonS B Murphy
May 9, 1996·The New England Journal of Medicine·J T SandlundW M Crist
Feb 23, 2000·Vaccine·J Tanaka
Jul 6, 2000·Medical and Pediatric Oncology·A MeralU Günay
Nov 6, 2001·Seminars in Hematology·C PatteD Sommelet

❮ Previous
Next ❯

Citations

Aug 26, 2010·Journal of Pediatric Hematology/oncology·Tiraje Tülin CelkanInci Yildiz
Aug 4, 2012·Journal of Pediatric Hematology/oncology·Carolina CervioGuillermo L Chantada
Nov 6, 2012·Revista brasileira de hematologia e hemoterapia·Keyla Christy Christine Mendes Sampaio CunhaMarcos Borato Viana
Feb 27, 2008·Pediatric Blood & Cancer·Raul C Ribeiro, John T Sandlund
Feb 8, 2011·Pediatric Blood & Cancer·Maria Luisa MoletiAnna Maria Testi
Aug 29, 2018·Hematology·Felix Gaytan-MoralesUNKNOWN Mexican Association of Pediatric Oncology and Hematology (AMOHP)
Mar 16, 2019·Science·Catherine G LamKathy Pritchard-Jones
Apr 11, 2018·BMJ Paediatrics Open·Hugo A MartijnSaskia Mostert

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.