Outcome of Conventional Adipose Tissue Grafting for Contour Deformities of Face and Role of Ex Vivo Expanded Adipose Tissue-Derived Stem Cells in Treatment of Such Deformities

The Journal of Craniofacial Surgery
Muhammad Mustehsan BashirMahmood S Choudhery

Abstract

To evaluate the outcomes of conventional fat grafting for facial contour deformities and to describe clinical outcome of a patient with contour deformity of face treated with ex vivo expanded adipose tissue-derived mesenchymal stem cells (ASCs) enriched fat graft. The Department of Plastic Surgery and Tissue Engineering and Regenerative Medicine Laboratory, King Edward Medical University/Mayo Hospital, Lahore, from September 2015 to September 2017. Patients with contour deformities of face requiring soft tissue augmentation were included. Fat was harvested, processed, and injected following a standard protocol. Both subjective and objective assessments were performed and complications were also noted. Twenty-five patients underwent 51 fat-grafting sessions over a period of 24 months. Eighteen (72%) patients underwent multiple fat-grafting sessions. Mean (standard deviation) soft tissue thickness after 72 hours and 6 months of first fat graft session was 18.62 (7.2) and 12.88 (6.21) mm, respectively, which corresponds to 30.77 (13)% reduction of transplanted fat. Physician and patient assessment scores were 3.42 (0.92) and 4 (1.04), respectively. Few minor complications were observed. In the patient undergoing ex vivo expanded A...Continue Reading

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Citations

Dec 14, 2019·Plastic and Reconstructive Surgery·Mahnood S Choudhery
Mar 1, 2019·The Journal of Craniofacial Surgery·Jack E BrookerKacey G Marra
Sep 22, 2019·Journal of Cosmetic Dermatology·Ghazala ButtMahmood S Choudhery
Sep 27, 2019·JAMA Facial Plastic Surgery·Kariem SharafFrank Haubner
Jan 28, 2020·Plastic and Reconstructive Surgery·Mahnood S Choudhery
Oct 13, 2020·Advanced Functional Materials·Sarah Van BelleghemJohn P Fisher
Nov 20, 2019·Clinics in Plastic Surgery·Shaoheng XiongLee L Q Pu
Nov 20, 2019·Clinics in Plastic Surgery·Nelson Sarto PiccoloMaria Thereza Sarto Piccolo

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