PMID: 11345173May 10, 2001Paper

Outcome of early hepatic portoenterostomy for biliary atresia

Journal of Pediatric Gastroenterology and Nutrition
D VolpertD H Perlmutter

Abstract

The outcome of the hepatic portoenterostomy (Kasai) procedure for biliary atresia is improved when it is performed before 90 days of age. However, it is not known whether intervention before 30 days is better than intervention between 30 and 90 days. The authors reviewed the records of all patients seen by the Pediatric Gastroenterology Service at St. Louis Children's Hospital from 1984-1999 to ascertain the outcome of patients who underwent Kasai procedure before or after 30 days of age. Of 92 patients with biliary atresia treated at St. Louis Children's Hospital over 15 years, 9 underwent the Kasai procedure before 30 days of age. Liver transplantation was necessary in 77.8% of these patients at a mean age of 11.0 +/- 4.26 months, as compared with 53.4% at 32.14 +/- 7.14 months for the remainder of the patients who underwent the procedure after 30 days of age. Although these data suggest that outcomes are worse for patients who undergo the procedure before 30 days of age, they may reflect a difference in the pathogenesis of biliary atresia that brings it to clinical attention earlier and may provide further evidence that biliary atresia is a phenotype for a number of distinct underlying disease processes.

References

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Nov 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Van EykenV J Desmet
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Citations

Dec 25, 2003·Journal of Pediatric Surgery·L W Ernest van HeurnPaul K H Tam
Jan 22, 2002·Current Opinion in Pediatrics·M R Narkewicz
Feb 28, 2014·World Journal of Gastroenterology : WJG·Elham TalachianNahid Nick-khah
Jan 14, 2011·Annual Review of Medicine·Kazuhiko Bessho, Jorge A Bezerra
Apr 2, 2004·Pediatrics International : Official Journal of the Japan Pediatric Society·Sema AydoğduRasit Vural Yagci
May 2, 2006·The Journal of Pediatrics·Benjamin L ShneiderUNKNOWN Biliary Atresia Research Consortium
May 27, 2015·Nature Reviews. Gastroenterology & Hepatology·Akihiro AsaiJorge A Bezerra
May 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David H Perlmutter, Ross W Shepherd
Sep 18, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Brendan C VisserRyutaro Hirose
Mar 26, 2008·Annals of Surgery·Mark DavenportEdward Howard
Jul 25, 2019·Journal of Pediatric Gastroenterology and Nutrition·Krupa R MysoreSanjiv Harpavat
Oct 17, 2003·Journal of Medical Screening·J E PowellA Green
Oct 7, 2004·Clinics in Liver Disease·David H Perlmutter
Jul 19, 2002·Clinics in Liver Disease·Milton J Finegold

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