Outcome of en bloc and single kidney transplantation from very young cadaveric donors

Transplantation
R SatterthwaiteR Mendez

Abstract

The optimal use of very young cadaveric kidneys (from donors less than 4 years old) remains controversial. High rates of technical complications and poor functional results compared with adult donor kidneys have been reported. The use of en bloc transplantation to overcome these problems has been advocated, although en bloc transplantation halves the number of potential transplants from very young donors. We studied the technical and functional results of 91 transplants from very young donors performed at our institution between 1984 and 1995. This included 59 single and 22 en bloc procedures involving first transplants and 7 single and 3 en bloc procedures involving retransplantation. Individual surgeon preference dictated the use of either the single or en bloc technique. Kidneys smaller than 6 cm tended to be transplanted en bloc, and lighter patients were generally given preference for receiving pediatric kidneys. Patients received sequential cyclosporine-based quadruple immunosuppression. En bloc kidneys had a 1-year and 5-year graft survival of 82% and 70%, respectively. Single kidneys had a 1-year and 5-year graft survival of 64% and 40%. Kidneys that avoided acute rejection episodes and that were transplanted into heavi...Continue Reading

References

Feb 1, 1975·Archives of Surgery·O Salvatierra, F O Belzer
Oct 1, 1977·British Journal of Urology·K DreikornR Horsch
Jan 1, 1976·Archives of Surgery·S J Silber
Aug 1, 1992·Journal of the American Society of Nephrology : JASN·B M BrennerE L Milford
Oct 1, 1991·The Journal of Urology·T A CreaghD M Murphy
Jan 1, 1988·Transplantation·J M HayesD R Steinmuller
Jul 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R N Fine
Oct 1, 1985·The Journal of Urology·J M BarryW M Bennett
Jan 1, 1974·Archives of Surgery·O S AndersenF K Merkel
May 1, 1974·The Journal of Urology·F K MerkelL R King
Apr 1, 1983·Annals of Surgery·J R SchneiderJ S Najarian
Dec 1, 1981·Transplantation·J H HongK M Butt
Jul 1, 1980·Kidney International·L LarssonP Wilton
May 27, 1994·Transplantation·P I TerasakiD W Gjertson
Jan 1, 1993·AJR. American Journal of Roentgenology·D S MemelT R Hakala
May 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B M Brenner, E L Milford
Mar 1, 1996·The Journal of Urology·A J Amante, B D Kahan
Feb 15, 1996·Transplantation·R S GastonJ J Curtis
Jan 1, 1908·The Journal of Experimental Medicine·A Carrel

❮ Previous
Next ❯

Citations

Dec 31, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Guido F LaubeThomas J Neuhaus
Jun 23, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Amr A El-HusseiniMohamed A Ghoneim
Dec 12, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Amr A El-HusseiniMohamed A Ghoneim
Feb 7, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mohan ShenoyNicholas J A Webb
Jan 8, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Murat DoganNejat Aksu
Nov 13, 2003·Transplantation Proceedings·K A BeasleyP P W Luke
Mar 20, 2003·Transplantation Proceedings·M F A El-SheikhD Talbot
Jan 1, 1998·Transplantation Proceedings·L H BanowskyF H Wright
Sep 2, 1998·Transplantation Proceedings·M R PuglieseP J Heering
Apr 17, 1998·Journal of the American College of Surgeons·D D NghiemH G Nghiem
Mar 10, 2001·Transplantation·A I Sánchez-FructuosoA Barrientos
Apr 20, 2002·Transplantation·Christoph StreyGuenter Kirste
Jun 28, 2003·Transplantation·Dai D Nghiem
Oct 28, 2003·Transplantation·Ana I Sánchez-FructuosoAlberto Barrientos
Aug 15, 2006·Transplantation·Kalathil K SureshkumarBarbara J Carpenter
Jun 16, 2010·Transplantation·Suverta BhayanaKanae Ishihara
Aug 22, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Rubin ZhangDouglas Slakey
Jun 11, 2010·Indian Journal of Nephrology·P ModiH L Trivedi
Sep 18, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·UNKNOWN European Renal Best Practice Transplantation Guideline Development Group
Jul 6, 2014·Current Opinion in Organ Transplantation·Krisztina Rusai, Attila J Szabo
Jun 30, 2014·Cell Biochemistry and Biophysics·Jin-feng LiWen-jun Shang
Jul 18, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jade S HiramotoRyutaro Hirose
Aug 16, 2000·Clinical Nuclear Medicine·F Morin, I Côté
Feb 16, 2013·Actas urologicas españolas·D LorenteJ Morote
Oct 26, 2010·Transplantation Proceedings·S BeltránL Pallardó
Jan 17, 2002·The Urologic Clinics of North America·C S ModlinA C Novick
Jan 26, 2005·Pediatric Transplantation·Ahmed A ShokeirAhmed B Shehab-El-Din
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Vikas R DharnidharkaRichard J Howard
Mar 25, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Shahid G FaridNiaz Ahmad
Mar 17, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Alexis BuggenhoutLuc De Pauw
Feb 18, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Gaetano CiancioGeorge W Burke
Nov 4, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S V McDiarmidS C Sweet
Feb 3, 2009·ANZ Journal of Surgery·Vincent W T LamHenry C C Pleass
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S J PelletierH W Sollinger
Mar 1, 2012·Pediatric Transplantation·Mickael AfanettiEtienne Berard
Oct 16, 2010·Pediatric Transplantation·Stuart M FlechnerVenkatesh Krishnamurthi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.