Outcome of Epstein-Barr virus-associated primary breast cancer

Molecular and Clinical Oncology
Chafika MazouniPierre-Marie Martin

Abstract

The presence of the Epstein-Barr-virus (EBV) has been reported to be a pathogenic factor in breast cancer (BC). We previously demonstrated the aggressiveness of EBV-positive BC. The purpose of the present study was to evaluate the effect of EBV on the prognosis of BC according to the BC phenotype. A total of 117 patients with primary BC previously tested for the presence of EBV were evaluated. The presence of the virus was evaluated in breast specimens using quantitative PCR (qPCR). Disease-free survival (DFS) and overall survival (OS) were evaluated for 4 molecular subtypes, namely luminal A and B (lumA and lumB, respectively), human epidermal growth factor receptor 2 (HER2) and triple-negative (TN) subtypes and according to the EBV status. EBV positivity was observed in 32.5% of the cases. TN, HER2 and lumB tumours were more frequent among EBV-BC cases (P=0.02). The DFS rates were different between BC subtypes (P=0.002), but the differences were not statistically significant when the cases were stratified according to the EBV status (P=0.08 for EBV-negative and 0.06 for EBV-positive cases). The OS rates were similar for BC subtypes (P= 0.50) and when the cases were stratified according to the EBV status (P=0.16 and P=0.67 for...Continue Reading

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Citations

May 17, 2018·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Dagmar HorakovaHelena Kollarova
Jul 26, 2019·Future Oncology·Mohammad FarahmandAhmad Tavakoli
May 26, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Fatima Zahra MouhMariam Amrani
Oct 31, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Malekpour Afshar RezaZeinali Nejad Hamid
Oct 9, 2021·Human Vaccines & Immunotherapeutics·Ishita GuptaHalema F Al-Farsi
Jul 17, 2019·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Qing'e JinShanna Wu

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