Outcome of extremely preterm infants randomized at birth to different PaCO2 targets during the first seven days of life

Biology of the Neonate
U ThomeW A Carlo

Abstract

Ventilation with higher PaCO(2) goals may reduce lung injury and bronchopulmonary dysplasia (BPD). The effect may be enhanced by using a higher PaCO(2) goal than in previous trials. To determine the clinical benefits and safety of higher PaCO(2) goals for ventilated preterm infants. Preterm infants with a gestational age between 23 and 28 completed weeks receiving mechanical ventilation within 6 h of birth were randomized to be managed with either a PaCO(2) target between 55 and 65 mm Hg (7.3- 8.7 kPa, minimal ventilation) or 35 and 45 mm Hg (4.7- 6.0 kPa, routine ventilation) for the first 7 days of life. The primary outcome measure was BPD, defined as need for mechanical ventilation or supplemental oxygen at 36 weeks postmenstrual age, or death. The neurodevelopmental status was assessed at 18-22 months corrected age. The trial was stopped early after enrolling 31% of the projected sample size. Enrolled infants had a median birth weight of 640 g. BPD or death occurred in 21/33 (64%) infants after minimal ventilation and 19/32 (59%) infants after routine ventilation. Minimal ventilation was associated with trends towards higher mortality and higher incidence of neurodevelopmental impairment, and a significantly increased combi...Continue Reading

References

Jul 1, 1991·Early Human Development·A GreenoughH R Gamsu
Jul 1, 1989·The Journal of Pediatrics·E N KraybillJ H Khan
Jan 10, 1985·The New England Journal of Medicine·M C McCormick
Apr 14, 1994·The New England Journal of Medicine·M J Tobin
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·D Dreyfuss, G Saumon
Nov 5, 1999·Pediatrics·G MarianiW A Carlo
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·J G LaffeyB P Kavanagh
Jan 15, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·J H Baumer
Jan 15, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·M W BeresfordD Manning
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
Oct 29, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·J D LangB A Freeman
Sep 10, 2002·The Journal of Pediatrics·Waldemar A CarloBarbara Stoll
Dec 26, 2003·American Journal of Respiratory and Critical Care Medicine·Erik R Swenson
Oct 13, 2004·American Journal of Respiratory and Critical Care Medicine·John D LangBruce A Freeman

❮ Previous
Next ❯

Citations

Jul 3, 2013·Early Human Development·Eduardo Bancalari, Nelson Claure
Dec 18, 2012·Archives of Disease in Childhood. Fetal and Neonatal Edition·Anton H van KaamUNKNOWN Neovent Study Group
Mar 28, 2008·Paediatric Anaesthesia·Anne GreenoughDeena Patel
Jan 26, 2017·Acta Paediatrica·Hesham Abdel-Hady, Basma Shouman
Feb 19, 2008·Clinics in Perinatology·J Davin Miller, Waldemar A Carlo
Mar 1, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Deepak Jain, Eduardo Bancalari
May 15, 2007·Current Opinion in Pediatrics·J Davin Miller, Waldemar A Carlo
Jul 17, 2008·Acta Paediatrica·Robert P Jankov, A Keith Tanswell
Dec 17, 2014·Current Opinion in Anaesthesiology·Maya ContrerasJohn G Laffey
Aug 5, 2011·Pediatric Pulmonology·Amir Kugelman, Manuel Durand
Mar 22, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nadine BrewFlora Y Wong
Sep 15, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Azhar MasoodA Keith Tanswell
Apr 18, 2018·Frontiers in Pediatrics·Alexandra Francoise Puchwein-SchwepckeUlrich H Thome
Apr 2, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jean-Claude HonoréSylvain Chemtob
Dec 20, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ipsita R GoswamiKhorshid Mohammad
May 1, 2021·Children·Tobias MuehlbacherManuel B Bryant
Jul 8, 2021·Pediatric Research·Sie Kei WongE J Molloy
Sep 8, 2012·Clinics in Perinatology·Julie RyuWaldemar A Carlo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.