Outcome of four high-risk pregnancies in female liver transplant recipients on tacrolimus immunosuppression

Transplantation Proceedings
Z Jabiry-ZieniewiczM Krawczyk

Abstract

Pregnancies in women after liver transplantation are considered high risk due to the greater rate of complications observed in immunosuppressed graft recipients. We report successful outcomes of four high-risk pregnancies in female liver transplant recipients on tacrolimus-based immunosuppression. The patients, aged 23 to 32 years, at the time of conception were 12 to 59 months from transplantation (mean 30 months). Preterm labor was the most important pregnancy complication observed in these patients. One episode of acute graft rejection was observed. A variable demand for tacrolimus was noted during pregnancy. Despite complications all four pregnancies were successful. The mean gestational age at delivery was 34.4 weeks. The birth weight of the newborns varied from 1410 to 3490 g (mean 2303 g) and the mean Apgar score was 8. No structural malformations or early complications were observed in the newborns. Excluding the patient with acute rejection, the remaining three cases showed all liver parameters to remain stable.

References

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Nov 21, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·V T ArmentiM J Moritz
Nov 2, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·C A Riely
Jul 10, 2003·Obstetrics and Gynecology·Sandor NagyVeronica Gomez-Lobo

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Citations

Oct 22, 2009·Clinical Reviews in Allergy & Immunology·Norbert Gleicher
Jan 12, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Chrysoula Margioula-SiarkouDavid Rousso
Nov 26, 2015·Critical Care Clinics·Stephen J Bacak, Loralei L Thornburg
May 31, 2011·Transplantation Proceedings·M L B CostaI F S F Boin
Jun 9, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·UNKNOWN Women in Hepatology Group, UNKNOWN Italian Association for the Study of the Liver (AISF)
Jan 1, 2013·Transplantation·Mary F HebertThomas R Easterling
Jul 7, 2009·Arquivos De Gastroenterologia·Mônica Beatriz ParolinMelina Pampuch

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