PMID: 10214828Apr 24, 1999Paper

Outcome of infants with hypoplastic left heart and Turner syndromes

Obstetrics and Gynecology
P M ReisC J van de Ven


To report the obstetric and neonatal outcomes of ten infants with hypoplastic left heart syndrome in association with Turner syndrome. The Pediatric Cardiovascular Surgery database at the University of Michigan was searched from 1990 to 1997, and obstetric and neonatal records of neonates with hypoplastic left heart syndrome and Turner syndrome were reviewed. There were 406 cases of hypoplastic left heart syndrome admitted during 8 years, of which ten (2.5%) also had Turner syndrome. Nine infants were delivered at term and one at 36 weeks. The mean (+/- standard deviation [SD]) gestational age at delivery was 38 +/- 1.2 weeks, and mean (+/-SD) birth weight was 2991 +/- 438 g. Delivery was vaginal in all cases, and no infant had an Apgar score at 5 minutes less than 7. Karyotype was 45, X in seven cases, and 45, X mosaic in three. Most infants had dysmorphic features at birth. All ten infants had first-stage reconstruction surgery for hypoplastic left heart syndrome. Only two survived and underwent second-stage palliation; both are alive currently, although with significant medical problems. For infants with hypoplastic left heart and Turner syndromes, regular obstetric management appears appropriate. Although staged reconstruct...Continue Reading


Sep 11, 1991·The Annals of Thoracic Surgery·William I Norwood
Jul 1, 1988·British Heart Journal·H van EgmondA Devloo-Blancquaert
Oct 9, 1986·The New England Journal of Medicine·L L BaileyE L Petry
Apr 1, 1994·American Heart Journal·R F Gillum
Sep 1, 1996·Annals of Surgery·Edward L Bove, T R Lloyd


May 25, 2012·The American Journal of Cardiology·Erin MadriagoMichael Silberbach
May 25, 2010·The Annals of Thoracic Surgery·Angira PatelConstantine D Mavroudis
Sep 9, 2015·Cardiology in the Young·Benjamin J LandisRobert B Hinton
Dec 4, 2009·Expert Review of Cardiovascular Therapy·Joshua Thomas, Anji T Yetman

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