Outcome of Inhaler Withdrawal in Patients Receiving Triple Therapy for COPD

Tuberculosis and Respiratory Diseases
Sae Ahm KimSang-Do Lee

Abstract

The purpose of this study was to document outcomes following withdrawal of a single inhaler (step-down) in chronic obstructive pulmonary disease (COPD) patients on triple therapy (long-acting muscarinic antagonist and a combination of long-acting β2-agonists and inhaled corticosteroid), which a common treatment strategy in clinical practice. Through a retrospective observational study, COPD patients receiving triple therapy over 2 years (triple group; n=109) were compared with those who had undergone triple therapy for at least 1 year and subsequently, over 9 months, initiated inhaler withdrawal (step-down group, n=39). The index time was defined as the time of withdrawal in the stepdown group and as 1 year after the start of triple therapy in the triple group. Lung function at the index time was superior and the previous exacerbation frequency was lower in the stepdown group than in the triple group. Step-down resulted in aggravating disease symptoms, a reduced overall quality of life, decreasing exercise performance, and accelerated forced expiratory volume in 1 second (FEV1) decline (54.7±15.7 mL/yr vs. 10.7±7.1 mL/yr, p=0.007), but there was no observed increase in the frequency of exacerbations. Withdrawal of a single inha...Continue Reading

References

Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Paul van der ValkCees van Herwaarden
Feb 14, 2003·Lancet·Peter CalverleyUNKNOWN TRial of Inhaled STeroids ANd long-acting beta2 agonists study group
Oct 14, 2003·Chest·Peter M A CalverleyUNKNOWN IOSLDE Study Group
Feb 21, 2007·Annals of Internal Medicine·Shawn D AaronUNKNOWN Canadian Thoracic Society/Canadian Respiratory Clinical Research Consortium
Feb 23, 2007·The New England Journal of Medicine·Peter M A CalverleyUNKNOWN TORCH investigators
Sep 4, 2007·Lancet·Jadwiga A Wedzicha, Terence A R Seemungal
Oct 7, 2008·The New England Journal of Medicine·Donald P TashkinUNKNOWN UPLIFT Study Investigators
Feb 21, 2009·COPD·Donald P TashkinSantosh T Varghese
Mar 23, 2010·Respiratory Medicine·J A van NoordP J G Cornelissen
May 27, 2010·Respiration; International Review of Thoracic Diseases·Peter J Barnes
Aug 18, 2010·International Journal of Chronic Obstructive Pulmonary Disease·Sonal Singh, Yoon K Loke
Sep 17, 2010·The New England Journal of Medicine·John R HurstUNKNOWN Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators
Sep 28, 2010·The American Journal of Medicine·Samy SuissaPierre Ernst
Mar 1, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Claudio Tantucci, Denise Modina
Sep 10, 2014·The New England Journal of Medicine·Helgo MagnussenUNKNOWN WISDOM Investigators

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.