Outcome of intracerebral haemorrhage patients pre-treated with statins

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
M GomisJ Roquer

Abstract

Statins treatment may have potential clinical impact in vascular disease beyond cholesterol lowering. Its benefits have been documented in cerebral ischaemia and in subarachnoid haemorrhage. In intracerebral haemorrhage (ICH), experimental models in statin-treated animals have better outcome than non-treated ones, but in humans the relationship is unclear. We investigated whether patients treated with statins before the onset of intracerebral haemorrhage have a better outcome at 3 months than patients without statins pre-treatment. Retrospective review of primary intracerebral haemorrhage case series from a prospective stroke register. We recorded demographics, vascular risk factors, previous statin treatment, Glasgow coma scale (GCS) at onset, ICH scale, hematoma volume and location, ventricular extension of the hematoma, and functional outcome at 3 months. The effect of prior statin treatment on good outcome (modified Rankin scale [mRS] 0 to 2) was analysed by logistic regression analysis. We included 269 patients (age 71.9 +/- 12.4, mean +/- SD, 152 males). Thirty-four patients (12.6%) were on prior statin treatment when admitted. There were no differences in fasting serum cholesterol and triglycerides levels between the sta...Continue Reading

References

Nov 1, 1989·Stroke; a Journal of Cerebral Circulation·K YanoC J MacLean
Aug 1, 1996·Stroke; a Journal of Cerebral Circulation·R U KothariJ Khoury
Apr 3, 2001·Stroke; a Journal of Cerebral Circulation·J C HemphillS C Johnston
May 11, 2001·The New England Journal of Medicine·A I QureshiD F Hanley
Sep 8, 2001·The New England Journal of Medicine·M O McCarron, J A Nicoll
Dec 7, 2002·Stroke; a Journal of Cerebral Circulation·Matthew J McGirtDavid S Warner
Jun 5, 2003·Annals of Neurology·Jieli ChenMichael Chopp
Apr 10, 2004·Stroke; a Journal of Cerebral Circulation·Joan Martí-FàbregasJosep-Lluis Martí-Vilalta
Apr 28, 2006·Nature Reviews. Immunology·John GreenwoodScott S Zamvil
Aug 11, 2006·The New England Journal of Medicine·Pierre AmarencoUNKNOWN Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators
Sep 2, 2006·Stroke; a Journal of Cerebral Circulation·Matthias Endres, Ulrich Laufs
Jun 16, 2007·Stroke; a Journal of Cerebral Circulation·Patrick D LydenUNKNOWN CHANT Trial Investigators
Aug 19, 2007·Neurocritical Care·Neeraj S NavalJuan R Carhuapoma
Aug 19, 2007·Neurocritical Care·Neeraj S NavalJuan R Carhuapoma
Mar 8, 2008·Stroke; a Journal of Cerebral Circulation·Jovita PonceTeresa Gasull
Apr 26, 2008·Stroke; a Journal of Cerebral Circulation·Emilie FitzMauriceEric E Smith
May 16, 2008·The New England Journal of Medicine·Stephan A MayerUNKNOWN FAST Trial Investigators

❮ Previous
Next ❯

Citations

Jan 12, 2011·Archives of Neurology·M Brandon WestoverSteven M Greenberg
Apr 30, 2010·Neurosurgical Review·Jorge Humberto Tapia-PérezThomas Schneider
Apr 9, 2013·Neurosurgical Review·Meng-Ta LiuYi-Chung Wu
Dec 6, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J RoquerA Ois
Aug 31, 2012·Stroke; a Journal of Cerebral Circulation·Guido J FalconeUNKNOWN International Stroke Genetics Consortium
Jul 23, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Jonathan WinklerLauren H Sansing
Dec 20, 2015·Pharmacotherapy·Andrea Sikora NewsomeEmily A Durr
Aug 27, 2015·International Journal of Stroke : Official Journal of the International Stroke Society·Jin-Man JungWoo-Keun Seo
Sep 21, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·J Humberto Tapia PérezChristopher Nimsky
Nov 10, 2010·Annals of Neurology·Alessandro BiffiUNKNOWN International Stroke Genetics Consortium
Apr 23, 2014·CNS Neuroscience & Therapeutics·Yue-Song PanUNKNOWN CNSR investigators
Jun 21, 2015·Current Atherosclerosis Reports·Arne LauerM Edip Gurol
Mar 25, 2014·American Journal of Human Genetics·Daniel WooUNKNOWN International Stroke Genetics Consortium
Jun 20, 2018·Stroke; a Journal of Cerebral Circulation·Sandro MariniUNKNOWN International Stroke Genetics Consortium
Mar 24, 2012·Stroke; a Journal of Cerebral Circulation·Dar DowlatshahiUNKNOWN Registry of the Canadian Stroke Network
Apr 6, 2013·Stroke; a Journal of Cerebral Circulation·William J DevanUNKNOWN International Stroke Genetics Consortium
Feb 7, 2019·JAMA Neurology·Sandro MariniUNKNOWN International Stroke Genetics Consortium
Oct 26, 2012·Neurosurgical Review·J H Tapia-PérezT Schneider
Nov 13, 2019·Neurology·Ching-Jen ChenAndrew M Southerland
Oct 15, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C LeiY Chen
Jun 2, 2016·Brain and Behavior·Shu-Yu TaiChen-Yu Chien
Oct 12, 2010·Stroke; a Journal of Cerebral Circulation·Christopher P Kellner, E Sander Connolly
Aug 4, 2021·Neurocritical Care·Kathryn N KearnsDale Ding
Aug 14, 2021·World Neurosurgery·Dominic NistalChristopher Kellner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.