PMID: 11332663May 3, 2001Paper

Outcome of invasive infections outside the central nervous system caused by Streptococcus pneumoniae isolates nonsusceptible to ceftriazone in children treated with beta-lactam antibiotics

The Pediatric Infectious Disease Journal
Sheldon L KaplanEllen R Wald

Abstract

To determine the outcome of children treated primarily with beta-lactam antibiotics for a systemic infection outside the central nervous system (CNS) caused by isolates of Streptococcus pneumoniae nonsusceptible to ceftriaxone (MIC > or = 1.0 microg/ml). Retrospective review of the medical records of children identified prospectively with invasive infections outside of the CNS caused by isolates of S. pneumoniae that were not susceptible to ceftriaxone between September, 1993, and August, 1999. A subset of this group treated primarily with beta-lactam antibiotics was analyzed for outcome. Infants and children with pneumococcal infections cared for at eight children's hospitals. Among 2,100 patients with invasive infections outside the CNS caused by S. pneumoniae, 166 had isolates not susceptible to ceftriaxone. One hundred patients treated primarily with beta-lactam antibiotics were identified. From this group 71 and 14 children had bacteremia alone or with pneumonia, respectively, caused by strains with an MIC of 1.0 microg/ml. Bacteremia or pneumonia caused by isolates with a ceftriaxone MIC > or = 2.0 microg/ml occurred in 6 and 5 children, respectively. Three children with septic arthritis and 1 with cellulitis had infectio...Continue Reading

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Citations

Mar 21, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J M Garcia-LechuzUNKNOWN Spanish Pneumococcal Study Network
May 31, 2008·Current Infectious Disease Reports·Eugene Leibovitz
Sep 27, 2003·International Journal of Antimicrobial Agents·Roman PallaresUNKNOWN Spanish Pneumococcal Infection Study Network
Sep 27, 2003·International Journal of Antimicrobial Agents·John G Gums
Jan 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John J RossDaniel S Shapiro
May 8, 2004·The Pediatric Infectious Disease Journal·Blanca E GonzalezSheldon L Kaplan
Jan 12, 2005·Pediatric Emergency Care·Jonathan SingerJonathan Taylor
Jun 2, 2006·Journal of Paediatrics and Child Health·Jonathan B GubbayRobin E Gilmour
Jul 27, 2004·Antimicrobial Agents and Chemotherapy·Stephanie J SchragUNKNOWN Active Bacterial Core Surveillance Team
Aug 14, 2010·Pediatric Annals·Michael Bolton, William Barson
Jan 20, 2009·Diagnostic Microbiology and Infectious Disease·Chih-Jung ChenYhu-Chering Huang
May 4, 2004·The Journal of Laboratory and Clinical Medicine·Charles Feldman
Apr 2, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J MaugeinB Poirier
Nov 19, 2003·Scandinavian Journal of Infectious Diseases·John Turnidge

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