Oct 5, 2019

Outcome of lesional epilepsy surgery: Report of the first comprehensive epilepsy program in Iran

Neurology. Clinical Practice
Jafar Mehvari HabibabadiSamden D Lhatoo

Abstract

We investigated the utility of epilepsy surgery and postoperative outcome in patients with lesional epilepsy in Iran, a relatively resource-poor setting. This prospective longitudinal study was conducted during 2007-2017 in Kashani Comprehensive Epilepsy Center, Isfahan, Iran. Patients with a diagnosis of intractable focal epilepsy, with MRI lesions, who underwent epilepsy surgery and were followed up ≥ 24 months, were included and evaluated for postoperative outcome. A total of 214 patients, with a mean age of 26.90 ± 9.82 years (59.8% men) were studied. Complex partial seizure was the most common type of seizure (85.9%), and 54.2% of the cases had auras. Temporal lobe lesions (75.2%) and mesial temporal sclerosis (48.1%) were the most frequent etiologies. With a mean follow-up of 62.17 ± 19.33 months, 81.8% of patients became seizure-free postoperatively. Anticonvulsants were reduced in 86% of the cases and discontinued in 40.7%. In keeping with previous studies, we found that seizure freedom rates were lower among patients with longer follow-up periods. We found high rates of seizure freedom after surgery in lesional epilepsy patients despite limited facilities and infrastructure; antiepileptic medications were successfully ...Continue Reading

  • References30
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References

  • References30
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Citations

Mentioned in this Paper

Study
Anticonvulsants
Follow-up
Environmental Infrastructure
Magnetic Resonance Imaging
Epilepsy
Evaluation
Drug Resistant Epilepsy
Antiepileptic Agents
Mesial Temporal Sclerosis

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