PMID: 8591677Oct 1, 1995Paper

Outcome of lower L-thyroxine dose for treatment of congenital hypothyroidism

Clinical Pediatrics
S P CamposM H MacGillivray

Abstract

The appropriateness of the recommended L-thyroxine dose (10-15 micrograms/kg/day) for the treatment of congenital hypothyroidism has been questioned because of the risk of iatrogenic hyperthyroidism. We report the outcome of 23 newborns with congenital primary hypothyroidism treated with 25 micrograms L-thyroxine per day (5.3-9.2 micrograms/kg/day) and followed for an average of 59 months. Serum thyroxine (T4) values increased (X = 11.4 +/- 2.7 micrograms/dL) within 4 weeks posttherapy; eight infants had T4 levels > or = 13 micrograms/dL on only half the currently recommended dose. Thyroid-stimulating hormone (TSH) values remained elevated in 18 of 21 patients for 2-21 months despite a high-normal T4. Psychometric tests were performed in 19 of the 23 patients. The mean Full Scale IQ for the congenital hypothyroid group (n = 16) was 101.4 +/- 13.2 with comparable Verbal and Performance IQ scores. Patients with a bone age (BA) of < or = 32 weeks or T4 < 2 micrograms/dL at initial evaluation had significantly Lower Verbal IQ scores. A standardized parent-report assessment of behavioral and emotional functioning revealed subgroup scale scores that were indistinguishable from nonclinical norms. We conclude that (1) average range IQ ...Continue Reading

References

Aug 1, 1990·The Journal of Pediatrics·J A Germak, T P Foley
Jul 1, 1988·Pediatric Research·J GlorieuxJ H Dussault
May 1, 1987·The Journal of Pediatrics·J RovetD Sorbara
Aug 1, 1986·Archives of Disease in Childhood·G MurphyD Grant
Aug 1, 1980·The Journal of Pediatrics·D Daneman, N J Howard
Mar 1, 1995·The Journal of Pediatrics·J F Rovet, R M Ehrlich
Jul 21, 1994·The New England Journal of Medicine·A D Toft
Jan 1, 1965·The Journal of Pediatrics·E L LIPTONL I GARDNER

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Citations

Feb 13, 2002·Thyroid : Official Journal of the American Thyroid Association·Mariacarolina SalernoAlfred Tenore
Aug 14, 1999·Thyroid : Official Journal of the American Thyroid Association·J F Rovet
Dec 17, 2005·Journal of Zhejiang University. Science. B·Ru-lai YangZheng-yan Zhao
Apr 21, 2007·Physiology & Behavior·Rosemary E ReidEugene O'Hare
Oct 1, 1995·Clinical Pediatrics·R M Ehrlich
Dec 14, 2006·Clinical Pediatrics·Makiko NakamizoKouhei Akazawa
Jan 13, 2018·The Journal of Clinical Endocrinology and Metabolism·Paulina E AleksanderHeiko Krude
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Sze May NgAlan M Weindling
Feb 26, 1999·Thyroid : Official Journal of the American Thyroid Association·G Van Vliet
Dec 13, 2016·International Journal of Endocrinology and Metabolism·Khaled RahmaniHamid Soori
Aug 6, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Hale TuhanEce Bober
Mar 12, 2005·Arquivos brasileiros de endocrinologia e metabologia·Roberto José R RamalhoManuel H Aguiar-Oliveira

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