Patients with occupational asthma, and their medical advisers, need valid information about the prognosis of their disease. A systematic review of the published literature on the symptomatic and functional outcomes of occupational asthma was carried out after avoidance of exposure to the causative agent. Through a full search of electronic and bibliographic sources, original studies documenting complete recovery from asthma (n = 39,1681 patients) or improvement in non-specific bronchial hyper-responsiveness (NSBHR; n = 28,695 patients) were identified. The median duration of follow-up was 31 (range 6-240) months for studies of symptomatic recovery and 37 (6-240) months for studies of NSBHR. Most studies were of patients recruited from special clinics. Reported rates of symptomatic recovery varied from 0% to 100%, with a pooled estimate of 32% (95% CI 26% to 38%). These rates were lower with increasing age (p = 0.019) and among clinic based populations (p = 0.053). Patients with the shortest durations of exposure (< or =76 months) had the highest rate of recovery (36%; 95% CI 25% to 50%), but the effect was not linear. The pooled prevalence of persistent NSBHR at follow-up was 73% (95% CI 66% to 79%). This figure was higher amon...Continue Reading
Effect of cessation of exposure to toluene diisocyanate (TDI) on bronchial mucosa of subjects with TDI-induced asthma
Bronchoalveolar lavage and morphology of the airways after cessation of exposure in asthmatic subjects sensitized to toluene diisocyanate
Occupational asthma due to various agents. Absence of clinical and functional improvement at an interval of four or more years after cessation of exposure
Persistent asthma due to isocyanates. A follow-up study of subjects with occupational asthma due to toluene diisocyanate (TDI)
Comparison of cellular and protein changes in bronchial lavage fluid of symptomatic and asymptomatic patients with red cedar asthma on follow-up examination
Patterns of improvement in spirometry, bronchial hyperresponsiveness, and specific IgE antibody levels after cessation of exposure in occupational asthma caused by snow-crab processing
Follow-up study of 232 patients with occupational asthma caused by western red cedar (Thuja plicata)
Immunologic and functional consequences of chemical (tetrachlorophthalic anhydride)-induced asthma after four years of avoidance of exposure
Clinical features and natural history of occupational asthma due to western red cedar (Thuja plicata)
Nonspecific and specific bronchial responsiveness in occupational asthma caused by platinum salts after allergen avoidance
Bronchial hyperresponsiveness and toluene diisocyanate. Long-term change in sensitized asthmatic subjects
Influence of inhaled steroids on recovery from occupational asthma after cessation of exposure: an 18-month double-blind crossover study
Follow-up of occupational asthma after removal from or diminution of exposure to the responsible agent: relevance of the length of the interval from cessation of exposure
Specific immunoglobulin E and immunoglobulin G antibodies to toluene diisocyanate-human serum albumin conjugate: useful markers for predicting long-term prognosis in toluene diisocyanate-induced asthma
Incidence by occupation and industry of acute work related respiratory diseases in the UK, 1992-2001
Recognition and surveillance of occupational asthma: a preventable illness with missed opportunities
An official American Thoracic Society proceedings: work-related asthma and airway diseases. Presentations and discussion from the Fourth Jack Pepys Workshop on Asthma in the Workplace
Diisocyanate-induced asthma in Switzerland: long-term course and patients' self-assessment after a 12-year follow-up
Human mesenchymal stem cells resolve airway inflammation, hyperreactivity, and histopathology in a mouse model of occupational asthma
The German experience 10 years after the latex allergy epidemic: need for further preventive measures in healthcare employees with latex allergy.
May the reduction of exposure to specific sensitizers be an alternative to work cessation in occupational asthma? Results from a follow-up study
Mild improvement in symptoms and pulmonary function in a long-term follow-up of patients with toluene diisocyanate-induced asthma
The use of a work-related asthma screening questionnaire in a primary care asthma program: an intervention trial
Diagnosis and management of work-related asthma: American College Of Chest Physicians Consensus Statement
How long do the systemic and ventilatory responses to toluene diisocyanate persist in dermally sensitized mice?
Occupational rhinitis in bell pepper greenhouse workers: determinants of leaving work and the effects of subsequent allergen avoidance on health-related quality of life
Persistence of asthma following allergen avoidance is associated with proTh2 myeloid dendritic cell activation
Defects in Plasmacytoid Dendritic Cell Expression of Inducible Costimulator Ligand and IFN-α Are Associated in Asthma with Disease Persistence
An official American Thoracic Society Workshop Report: presentations and discussion of the fifth Jack Pepys Workshop on Asthma in the Workplace. Comparisons between asthma in the workplace and non-work-related asthma
Are high- and low-molecular-weight sensitizing agents associated with different clinical phenotypes of occupational asthma?
Allergy and Asthma
Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.
This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.