PMID: 7939592Jun 30, 1994Paper

Outcome of occupational asthma due to cobalt hypersensitivity

The Science of the Total Environment
G Pisati, S Zedda

Abstract

We performed a follow-up study on nine subjects with occupational asthma due to cobalt hypersensitivity confirmed by a specific bronchial provocation test. Both at diagnosis and at the two follow-up visits (1 and 3 years after the diagnosis, respectively), we graded the severity of asthmatic symptoms and the need for antiasthma treatment and performed lung function tests, measurement of airways responsiveness to methacholine (PD15) and skin tests. The evolution of the disease was established on the basis of the increase or decrease in asthmatic symptoms and the requirements for medication, FEV1 and PD15. After cessation of exposure, two subjects recovered, five improved and one remained stable; the subject who carried on working in the same environment deteriorated. The improvement in symptoms, medication need and lung function occurred earlier and in a larger number of patients than the improvement in methacholine hyperreactivity. At follow-up, the inhalation test with cobalt was repeated on three subjects who had stopped exposure and were asymptomatic and again they had bronchoconstriction. Our data show that early diagnosis and early removal from exposure after the onset of asthma are important factors for a favourable evolu...Continue Reading

References

Sep 1, 1988·Clinical Allergy·T ShirakawaK Morimoto
Aug 1, 1986·Clinical Reviews in Allergy·M Chan-Yeung
Jul 1, 1986·British Journal of Industrial Medicine·Y KusakaS Goto
Sep 1, 1980·Thorax·I SjögrenO Zetterström
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Feb 20, 2008·Occupational and Environmental Medicine·Paul Cullinan

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Citations

Jun 30, 1994·The Science of the Total Environment·E SabbioniP Seghizzi
Mar 24, 2010·Occupational Medicine·R SauniJ Uitti
Sep 28, 2012·Journal of Occupational Medicine and Toxicology·Xaver BaurHenning Vellguth
Dec 19, 2015·Journal of Environmental and Public Health·Ellen YardAmha Kebede
May 13, 2011·The Cochrane Database of Systematic Reviews·Gerda J de GroeneJos H Verbeek
Oct 9, 2019·The Cochrane Database of Systematic Reviews·Paul K HennebergerStefania Curti
Jul 14, 2000·American Journal of Industrial Medicine·V van KampenX Baur

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