Outcome of Patients with Borderline Resectable Pancreatic Cancer in the Contemporary Era of Neoadjuvant Chemotherapy

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Ammar A JavedJin He

Abstract

Approximately, 20% of patients with pancreatic ductal adenocarcinoma have resectable disease at diagnosis. Given improvements in locoregional and systemic therapies, some patients with borderline resectable pancreatic cancer (BRPC) can now undergo successful resection. The outcomes of patients with BRPC after neoadjuvant therapy remain unclear. A prospectively maintained single-institution database was utilized to identify patients with BRPC who were managed at the Johns Hopkins Pancreas Multidisciplinary Clinic (PMDC) between 2013 and 2016. BRPC was defined as any tumor that presented with radiographic evidence of the involvement of the portal vein (PV) or superior mesenteric vein (SMV) that was deemed to be technically resectable (with or without the need for reconstruction), or the abutment (< 180° involvement) of the common hepatic artery (CHA) or superior mesenteric artery (SMA), in the absence of involvement of the celiac axis (CA). We collected data on treatment, the course of the disease, resection rate, and survival. Of the 866 patients evaluated at the PMDC during the study period, 151 (17.5%) were staged as BRPC. Ninety-six patients (63.6%) underwent resection. Neoadjuvant chemotherapy was administered to 142 patient...Continue Reading

References

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Citations

Jan 1, 2020·World Journal of Surgical Oncology·Keishi SugimachiYasushi Toh
Jun 23, 2020·Gastroenterology Research and Practice·Ricky H BhogalAamir Z Khan
Dec 15, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Hryhoriy LapshynLouisa Bolm
Feb 4, 2021·Annals of Gastroenterological Surgery·Keinosuke IshidoTaiichi Wakiya
Nov 21, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Daniel L P HolyoakeMaria A Hawkins
Apr 23, 2021·Cancer Control : Journal of the Moffitt Cancer Center·Angela Y JiaJeffrey Meyer
Aug 28, 2021·Annals of Surgical Oncology·Georgios GemenetzisJin He
Jan 8, 2022·World Journal of Surgery·Ammar A JavedJin He

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