Outcome of patients with lithium poisoning at a far-east poison center

Human & Experimental Toxicology
Yen-Ching LeeTzung-Hai Yen

Abstract

Lithium is a popular medication for bipolar disorder, but very little work has been done to study Asian patients with lithium poisoning. A total of 21 out of 7140 poisoned patients were referred for management of lithium poisoning between 2000 and 2009. Patients were stratified according to blood lithium level, that is mild-to-moderate (<2.5 mEq/L) or severe (≥2.5 mEq/L) poisoning. Demographic, clinical, and laboratory data were obtained for analysis. Mortality rates were also analyzed. There were no significant differences between both groups for the baseline variables such as poisoning patterns, age, sex, smoking habit, alcohol consumption, or medical history of diabetes mellitus or hypertension (p > 0.05). Patients with severe poisoning had a greater distribution of severe neurological symptoms (mild/moderate/ severe: 11.1%/44.4%/44.4% versus 58.35%/16.65%/8.3%, p < 0.05), cardiovascular symptoms (66.6% versus 16.6%, p < 0.05), and renal impairment (urea nitrogen/creatinine: 27.1 ± 17.8/ 1.9 ± 1.3 mg/dL versus 14.1 ± 7.1/ 1.3 ± 0.6 mg/dL, p < 0.05) than patients with mild-to-moderate poisoning. Most patients were treated with saline diuresis (9 patients [100%] with severe poisoning versus 9 patients [75.0%] with mild-to-mode...Continue Reading

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Citations

Oct 31, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anne-Sophie HanakBruno Mégarbane
Jun 3, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Dominique VodovarBruno Mégarbane
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Apr 26, 2018·Nano Letters·Rebecca L BallKathryn A Whitehead

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