Outcome of perioperative hemostatic management in patients with hemophilia without inhibitors undergoing 161 invasive or surgical procedures

Journal of the Chinese Medical Association : JCMA
Kwok-Man TongShian-Shiang Wang

Abstract

Perioperative management of persons with hemophilia (PWH) is a challenge for surgeons and hematologists. Reductions in mortality rate and complications have been achieved since the introduction of clotting factor concentrates (CFCs), which improve hemostatic control. However, there is no clear consensus on the optimal dosing of CFC administration. The aim of this study was to evaluate the outcome of PWH without inhibitors in patients undergoing invasive or surgical procedures. A total of 161 procedures, including 57 major and 104 minor ones were retrospectively reviewed. The characteristics of PWH, age at procedure, duration and total amount of CFC administration during the perioperative period, hemostatic adequacy, and complications were summarized. The study showed a low rate of bleeding (1.2%), infection (0%), thromboembolic event (0%), and inhibitor development (0%). The results revealed the doses and duration of CFC administration for several major and minor procedures which were capable of achieving excellent hemostatic control.

References

Jan 24, 2006·Seminars in Hematology·Jørgen Ingerslev, Ivan Hvid
May 16, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·C HermansUNKNOWN European Haemophilia Therapy Standardisation Board
Oct 20, 2009·American Journal of Surgery·Georg GoldmannMarcus Overhaus
Jul 11, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·A SrivastavaUNKNOWN Treatment Guidelines Working Group on Behalf of The World Federation Of Hemophilia
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Jul 16, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·John ChapinMaria DeSancho

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Citations

Apr 25, 2020·Molecular Therapy. Nucleic Acids·Chun-Yu ChenCarol H Miao
Aug 8, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yeu-Chin ChenSheng-Hao Wang

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