Outcome of prenatally detected cardiac malformations

The American Journal of Cardiology
J F SmytheC S Kleinman

Abstract

Reliable, prenatal detection of congenital heart disease has become possible over the past decade with the evolution of fetal echocardiography. We have documented the outcome of 170 cardiac defects diagnosed prenatally since 1984. Of 170 cases, 55 (32%) had major extracardiac malformations and 45 (28%) chromosomal abnormalities (16 had both). Elective termination was chosen in 77 (45%) pregnancies. Of 93 continuing pregnancies 15 were stillborn and 43 died postnatally (48% of these fetuses and infants had extracardiac or chromosomal anomalies, or both). Thirty-five patients survive at 1 to 80 months (mean 36). Aneuploidy or extracardiac defects are present in 20% of survivors. Nonimmune hydrops secondary to cardiac failure was present in 7 continuing pregnancies and none of these patients survived. The prognosis of prenatally diagnosed cardiac lesions is negatively influenced by the presence of cardiac failure, aneuploidy or extracardiac malformations, or a combination of these. Optimal counseling and management requires the identification of these conditions when present.

References

Mar 1, 1991·Archives of Disease in Childhood·G K SharlandL D Allan
Jan 1, 1991·Journal of the American College of Cardiology·L K HornbergerK L Reed
Jan 1, 1990·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N H Silverman, K G Schmidt
Dec 1, 1989·International Journal of Cardiology·L D AllanD C Crawford
May 1, 1986·American Journal of Obstetrics and Gynecology·J A CopelC S Kleinman
Oct 1, 1988·Archives of Disease in Childhood·I A ParnessR VanPraagh
Feb 1, 1988·American Journal of Obstetrics and Gynecology·J A CopelC S Kleinman
Aug 1, 1988·American Journal of Obstetrics and Gynecology·K A BergJ A Boughman
Sep 1, 1987·American Journal of Obstetrics and Gynecology·J A CopelC S Kleinman
Apr 1, 1986·Ultrasound in Medicine & Biology·J A Copel, C S Kleinman
Jun 1, 1984·Radiology·B S MahonyM S Golbus
Jan 1, 1982·Cytogenetics and Cell Genetics·E B Hook

❮ Previous
Next ❯

Citations

Mar 24, 1998·Prenatal Diagnosis·U Gembruch
Apr 1, 1994·Prenatal Diagnosis·V ColloridiP Gallo
Jul 11, 2006·Pediatric Cardiology·Ioannis Germanakis, Stavros Sifakis
May 1, 1994·Journal of the American College of Cardiology·R WhittemoreX Castellsague
Oct 3, 1998·Early Human Development·J G RodriguezP Soothill
Jun 2, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M Meyer-WittkopfG Sholler
Jun 2, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E T JaeggiS G Cooper
Dec 7, 2011·American Journal of Perinatology·Fadi G MirzaLynn L Simpson
Oct 1, 1995·Journal of Paediatrics and Child Health·D J Penny, R G Weintraub
Jul 1, 1997·Archives of Disease in Childhood. Fetal and Neonatal Edition·G Sharland
Jul 1, 1997·Archives of Disease in Childhood. Fetal and Neonatal Edition·M Eronen
Apr 1, 1994·British Heart Journal·J WyllieS Hunter
Sep 1, 1994·Archives of Disease in Childhood. Fetal and Neonatal Edition·C K Phoon
Jun 26, 2007·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Sheng-Mou HsiaoFon-Jou Hsieh
May 1, 1994·American Journal of Obstetrics and Gynecology·C J Limb, L B Holmes
Jan 29, 2011·The Journal of Obstetrics and Gynaecology Research·Clarissa VelayoYoshitaka Kimura
Sep 4, 2013·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·Lami Yeo, Roberto Romero
Sep 30, 2010·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·L YeoS Hassan
Jul 20, 1999·Current Problems in Pediatrics·C K PhoonM Rutkowski
Feb 26, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Gengi Satomi
May 15, 1996·The American Journal of Cardiology·C K PhoonN H Silverman
Apr 6, 2004·Obstetrics and Gynecology Clinics of North America·Lynn L Simpson
Aug 19, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M GarciaE Hernandez-Andrade
Feb 13, 2001·Seminars in Neonatology : SN·G Sharland
Mar 3, 2004·Journal of Clinical Ultrasound : JCU·Lynn L Simpson
Jun 17, 2003·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S LeviUNKNOWN Eurofetus study group
Oct 27, 2004·Prenatal Diagnosis·Mark K Friedberg, Norman H Silverman
Oct 13, 2006·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G OggèT Todros
Feb 16, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S FechnerM Meyer-Wittkopf
Nov 4, 1993·Quality in Health Care : QHC·N FreemantleJ Webb
Aug 15, 2019·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Michael GembickiJan Weichert
Aug 13, 2008·Journal of Cardiovascular Medicine·Maria G RussoRaffaele Calabrò
Jun 26, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Michael GembickiJan Weichert
Jul 10, 2020·The International Journal of Cardiovascular Imaging·Mingming MaBowen Zhao
Jan 28, 2006·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Benjamin D HamarJoshua A Copel
Sep 1, 2013·Cardiovascular Engineering and Technology·Sowmya Balasubramanian, Theresa A Tacy
May 25, 2002·Scandinavian Cardiovascular Journal : SCJ·Drude Fugelseth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Related Papers

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
J A CopelC S Kleinman
© 2021 Meta ULC. All rights reserved