PMID: 16617193Apr 18, 2006Paper

Outcome of radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma refractory to Helicobacter pylori eradication therapy

Internal Medicine
Mitsushige SugimotoAkira Hishida

Abstract

Most low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphomas respond to eradication of H. pylori, however, some are refractory. The effectiveness of radiotherapy for MALT lymphoma refractory to H. pylori eradication has been demonstrated. However, the long-term outcome and associated late radiation morbidity of radiotherapy for gastric MALT lymphoma are unclear. We evaluated the efficacy of radiotherapy and the radiation-associated adverse effects for gastric MALT lymphoma refractory to H. pylori eradication therapy. Eighteen patients with H. pylori-positive gastric MALT lymphoma received H. pylori eradication therapy, of which three patients refractory to eradication of H. pylori were subsequently treated with irradiation (median 39 Gy, range 36-40 Gy). Efficacy of radiotherapy and associated radiation morbidity were evaluated. Adverse events were evaluated according to RTOG and NCI-CTC criteria. Radiation was well tolerated. All three patients treated with radiotherapy achieved complete remission, which was sustained for a median follow-up period of 42.0 months (range, 24-72 months). As acute radiation side effects, all patients experienced mild nausea (Grade 1 by RTOG and 1 point [1 category] in NCI-CTC). One pa...Continue Reading

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Citations

Feb 17, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Mitsushige Sugimoto, Yoshio Yamaoka
Dec 17, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P G GobbiG R Corazza
Feb 9, 2010·Journal of Gastroenterology and Hepatology·Mitsushige SugimotoYoshio Yamaoka
Apr 18, 2006·Internal Medicine·Tomoya Maeda, Nozomi Niitsu
Mar 12, 2010·World Journal of Gastroenterology : WJG·Mitsushige SugimotoTakahisa Furuta
Oct 10, 2013·World Journal of Gastroenterology : WJG·Sang-Won KimKyoung-Mee Kim
Jun 18, 2009·The American Journal of Gastroenterology·Angelo ZulloDino Vaira
Apr 25, 2018·World Journal of Gastroenterology : WJG·Mitsushige SugimotoAkira Andoh

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