Outcome of rectal cancer surgery in obese and nonobese patients: a meta-analysis

World Journal of Surgical Oncology
Yuan QiuHua Yang

Abstract

The escalating global epidemic of obesity is of worldwide concern because of its association with serious negative effects on health. The technical difficulty of rectal cancer surgery is exacerbated in obese patients, which may compromise outcomes. High-quality, relevant evidence is limited. This meta-analysis aims to assess the outcomes of rectal cancer surgery in obese and nonobese patients. The electronic databases Pubmed, Medline, Embase, Web of Science, and the Cochrane Library were used to search for articles that evaluated the outcomes of rectal cancer surgery in obese and nonobese patients. Fixed-effects and random-effects models were used to calculate the combined overall effect sizes of pooled data. Data are presented as odds ratios (OR) or weighted mean differences (WMD) with 95% confidence intervals (CIs). Ten appropriate observational studies were identified from 290 published articles. In the obese group, conversion rates (OR 2.78; 95% CI 1.67-4.61), overall morbidity (OR 1.36; 95% CI 1.25-1.47), anastomotic leak (OR 3.94; 95% CI 1.88-8.24), wound infection (OR 2.22; 95% CI 1.47, 3.36), and pulmonary events (OR 2.10; 95% CI 1.18, 3.74) were all significantly increased. For pathological results, no statistical diff...Continue Reading

References

Jul 20, 1994·JAMA : the Journal of the American Medical Association·R J KuczmarskiC L Johnson
Apr 8, 1998·The British Journal of Surgery·E RullierM Parneix
Mar 26, 2003·International Journal of Radiation Oncology, Biology, Physics·C A M MarijnenUNKNOWN Cooperative investigators of the Dutch Colerectal Cancer Group
Oct 8, 2003·Pathology Oncology Research : POR·Dénes GörögFerenc Perner
Jan 15, 2004·British Journal of Anaesthesia·B S von Ungern-SternbergA Reber
Feb 5, 2004·The Annals of Thoracic Surgery·Thanos AthanasiouBrian Glenville
Feb 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey A MeyerhardtCharles S Fuchs
Aug 19, 2007·The British Journal of Surgery·H ThorpeUNKNOWN Medical Research Council Conventional versus Laparoscopic-Assisted Surgery In Colorectal Cancer Trial Group
Sep 28, 2007·Diseases of the Colon and Rectum·Kelly A GendallFrank A Frizelle
Feb 29, 2008·World Journal of Surgery·Avo ArtinyanRobert W Beart
Jan 1, 2009·Surgical Endoscopy·Thierry BègeJean-Robert Delpero
Jul 8, 2010·The Journal of Surgical Research·Courtney J BalentineDavid H Berger
Jul 9, 2010·Journal of the American College of Surgeons·Hueylan ChernMartin R Weiser
Jan 14, 2011·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Tayfun KarahasanogluEbru Kirbiyik
May 18, 2011·Archives of Surgery·Elizabeth C WickMartin A Makary
Jul 18, 2012·World Journal of Surgical Oncology·Tolutope OyasijiPonnandai Somasundar
Oct 6, 2012·Southern Medical Journal·Karl MrakJörg Tschmelitsch
Mar 29, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Q DenostE Rullier
May 14, 2014·Diseases of the Colon and Rectum·Jennifer E HrabeJohn C Byrn
Jul 22, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·L BokeyO F Dent

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Citations

Nov 15, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·N de'AngelisUNKNOWN EuMaRCS Study Group
Dec 19, 2017·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Onur BayraktarTayfun Karahasanoğlu
May 27, 2020·Wiener klinische Wochenschrift·Maja KarinMilenko Bevanda
Jun 7, 2020·Langenbeck's Archives of Surgery·Dagmar Schaffler-SchadenHelmut Weiss
Sep 29, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Richard GarfinkleMarylise Boutros
Feb 12, 2019·Diseases of the Colon and Rectum·Jia Lin NgChucheep Sahakitrungruang
Jul 31, 2019·The American Journal of Nursing·Anne Katz
Mar 5, 2021·Journal of Gastrointestinal Cancer·Dhruvin H HirparaSami A Chadi

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