Outcome of retinoblastoma following limited sessions of intra-arterial chemotherapy in iran

Iranian Journal of Radiology : a Quarterly Journal Published by the Iranian Radiological Society
Fariba GhassemiMohammad Taher Rajabi

Abstract

The management of retinoblastoma remains a challenge to the multidisciplinary team, particularly as treatment affects not only visual outcomes, but also ocular retention and morbidity. Management of retinoblastoma has evolved over the past two decades. To report the result of intra-ophthalmic artery chemotherapy (IAC) for the treatment of refractory and advanced retinoblastoma tumors. All patients who had failed to respond adequately to previous treatments and six naive patients with advanced retinoblastoma, receiving IAC between 2009 and 2012, were included in this institutional interventional case series. The patients received 1-2 treatments of IAC given 4-8 weeks apart. Complete response was defined as regressed tumor and complete disappearance of seeding clinically and partial response was defined as partial regression of the tumor with live parts of the tumor and/or lessening of seeds, but not complete disappearance of them clinically. A total of 24 eyes of 24 patients were treated with IAC during the study period. The mean age at the time of IAC was 38.9 months (14-120 months), and the mean follow-up was 16.8 months (3-36 months) after IAC. Tumor control was achieved in 14 eyes (58.3%). Type 3 (combined fleshy and calcifi...Continue Reading

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Citations

May 20, 2019·Journal of Neurointerventional Surgery·Krishnan RavindranWaleed Brinjikji
Feb 13, 2020·Journal of Ophthalmology·Aleksandra Pekacka
Aug 18, 2017·International Journal of Retina and Vitreous·Camila V VenturaTimothy G Murray
Apr 8, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J RunnelsB Fiani
May 28, 2021·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Carol L ShieldsPascal Jabbour
Feb 1, 2020·Ocular Oncology and Pathology·Pukhraj RishiR Ravikumar

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