Abstract
Enteroviruses (EV) and human parechoviruses (HPeV) are known and emerging cause of sepsis-like illnesses in infants; however, testing is not yet routine. We retrospectively evaluated the number of diagnosed EV/HPeV infections in children under the age of 5 years who presented with sepsis-like illness or meningitis in Cornwall, UK, before and after routine implementation of viral screening of cerebrospinal fluid samples. During the 4-year period prior to routine testing, we identified 20 cases of EV meningitis and no cases of HPeV. In the year after introduction of routine screening, 27 cases of EV and 14 cases of HPeV were identified in 1 year. The majority of EV/HPeV infections occurred among children under 3 months old between May and August. Clinical and laboratory characteristics of EV and HPeV infections were mostly indistinguishable. We found that CSF pleocytosis and biochemistry-based testing strategy could miss 48.1 and 78.5% of EV and HPeV cases, respectively. With routine viral screening, the mean length of hospital stay (3.8 vs 5.9 days, P < 0.001) and antibiotic days (2.8 vs 4.7 days, P < 0.001) were significantly reduced in EV/HPeV-positive cases compared to a similar cohort without any detectable microbial aetiolo...Continue Reading
References
Apr 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H A Rotbart
Sep 15, 2004·Journal of Clinical Microbiology·William S MulfordGregory A Storch
Dec 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K S M BenschopK C Wolthers
Sep 29, 2006·The Pediatric Infectious Disease Journal·Nino KhetsurianiMark Pallansch
Jun 19, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Katja C WolthersDasja Pajkrt
May 22, 2009·The Journal of Infectious Diseases·H HarvalaP Simmonds
Mar 18, 2011·Journal of Medical Virology·Heli HarvalaPeter Simmonds
Sep 28, 2012·Journal of Clinical Microbiology·Justin SharpRangaraj Selvarangan
Jan 1, 2014·Emerging Infectious Diseases·Thea K FischerAlex Y Nielsen
Jan 21, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J G WildenbeestD Pajkrt
Apr 3, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Susanna EspositoHubert G M Niesters
Apr 9, 2014·Early Human Development·Antonio PirallaFausto Baldanti
Jul 22, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S KadambariS N Ladhani
Nov 27, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·V A JanesK S Benschop
Jan 13, 2015·European Journal of Pediatrics·Stefania VergnanoHermione Lyall
Jun 18, 2015·Emerging Infectious Diseases·Germaine CummingVicky Sheppeard
Jan 23, 2016·Pediatrics·Philip N BrittonUNKNOWN PAEDS-ACE Investigators
Sep 3, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Julian W TangSrini Bandi
Citations
Jun 4, 2019·Human Vaccines & Immunotherapeutics·Federico Martinón-TorresRobb Butler
Oct 2, 2020·Japanese Journal of Infectious Diseases·Taito KitanoSayaka Yoshida
Jun 11, 2019·Journal of Medical Virology·Paul C TurnerSiba P Paul
Jun 18, 2019·The Pediatric Infectious Disease Journal·Hana Mijovic, Manish Sadarangani
Jan 15, 2019·European Journal of Pediatrics·Ted M T van HinsberghCharlie C Obihara
Apr 18, 2020·BMC Pediatrics·Paolo PaioniChristoph Berger
Jul 28, 2020·Journal of Clinical Medicine·Kacper ToczylowskiArtur Sulik
Oct 13, 2020·The Journal of Pediatrics·Cristina Tomatis SouverbielleGuliz Erdem
Feb 2, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Basheer NassrallahJacob Genizi
Oct 16, 2020·Journal of Clinical Microbiology·Brian R LeeRangaraj Selvarangan
Jul 28, 2020·The Lancet Child & Adolescent Health·Ted M T van HinsberghCharlie C Obihara
Apr 4, 2021·Viruses·Lieke BrouwerDasja Pajkrt
Mar 29, 2021·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·S MarchandM Coste-Burel
Jul 11, 2021·Archives of Disease in Childhood. Education and Practice Edition·Siba Prosad PaulPaul Anthony Heaton
Jul 27, 2021·Virologica Sinica·Lamprini PosnakoglouAthanasios Michos