Outcome of seizures in the general population after 25 years: a prospective follow-up, observational cohort study

Journal of Neurology, Neurosurgery, and Psychiatry
Gail S BellJosemir W Sander

Abstract

We investigated long-term (to 25 years) seizure prognosis and survival in people with newly diagnosed epilepsy in the community. We explored whether prognosis is different in those with epilepsy (>2 unprovoked seizures) and those with a single seizure at presentation. This is a prospective observational cohort study of people with newly diagnosed seizures. We investigated seizure outcome and survival in people presenting with a single seizure and in those presenting with >2 seizures (epilepsy). 695 people (median follow-up 23.6 years) had unprovoked epileptic seizures. For seizure analysis we excluded 38 people with missing data leaving 657 (309 male, and 249 aged <18 years). Seizures recurred in 67%. The 354 people with epilepsy were only slightly more likely to have further seizure recurrence than the 302 people with a single seizure at presentation (HR 1.32, 95% CI 1.09 to 1.59). In 327 people with complete follow-up, 268 (82%, 95% CI 77% to 86%) were in terminal remission; (80%, (95% CI 73% to 85%) in those with epilepsy at presentation). Premature mortality was increased in people with epilepsy (standardised mortality ratio 1.67; 95% CI 1.40 to 1.99) and those with a single seizure at presentation (standardised mortality r...Continue Reading

References

Dec 1, 1979·Epilepsia·J F AnnegersL R Elveback
Aug 1, 1980·Epilepsia·W A HauserL R Elveback
Jan 13, 2006·Brain : a Journal of Neurology·Matti Sillanpää, Dieter Schmidt
Feb 22, 2008·Epilepsia·Anne T Berg
Dec 24, 2010·Epilepsia·Aidan NeliganJosemir W Sander
Feb 1, 2011·Brain : a Journal of Neurology·Aidan NeliganJosemir W Sander
Oct 19, 2011·Epilepsia·Christine St Germaine-SmithNathalie Jette
Jun 14, 2012·Epilepsia·Athanasios GaitatzisJosemir W Sander
Jan 1, 2011·BMJ : British Medical Journal·Douglas G Altman, J Martin Bland
Sep 4, 2012·Handbook of Clinical Neurology·Aidan NeliganJosemir W Sander
Apr 16, 2014·Epilepsia·Robert S FisherSamuel Wiebe

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Citations

Sep 21, 2016·Seizure : the Journal of the British Epilepsy Association·M Sillanpää, D Schmidt
Apr 5, 2017·Epilepsia·Matti SillanpääShlomo Shinnar
Aug 2, 2016·Lancet Neurology·Nathalie JettéMark R Keezer
Jan 25, 2018·Brain : a Journal of Neurology·Christopher D WhelanSanjay M Sisodiya
Oct 7, 2017·Epilepsia·Peter R Camfield, Carol S Camfield
Oct 15, 2019·Brain : a Journal of Neurology·Costin LeuDennis Lal
May 1, 2020·Acta Neurologica Scandinavica·Jonathan J Halford, Jonathan C Edwards
Mar 30, 2021·Epilepsy Research·Mohammad AlsumailiFaisal Alotaibi
Aug 14, 2021·Neuropathology and Applied Neurobiology·Andre AltmannSanjay M Sisodiya

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