Outcome of thyroid gene expression classifier testing in clinical practice

The Laryngoscope
Robert L Witt

Abstract

Gene expression classifiers can safely reduce diagnostic thyroid surgery for fine-needle aspiration cytology (FNAC) indeterminate thyroid nodules. Retrospective review, single-institution, single-practice surgeon. Three-year retrospective review of indeterminate FNAC that went on to gene expression classifier testing. A total of 520 patients met American Thyroid Association guideline criteria for surgeon-performed ultrasound-guided FNAC for a thyroid nodule with on-site cytopathology. The indeterminate (Bethesda III or IV) FNAC rate was 9%. Prevalence of malignancy in FNAC indeterminate was 21%. Thirty-two cases went on to gene expression classifier testing. Fourteen were benign, 15 suspicious, and three with no result. Benign gene expression classifier testing had an estimated negative predictive value of 100% during the study period. These patients have been observed for a mean and median duration of 14 and 7 months, respectively. In this small series, 14 of 29 patients with indeterminate FNAC were spared diagnostic surgery. 4 Laryngoscope, 126:524-527, 2016.

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Citations

Jul 26, 2017·Thyroid : Official Journal of the American Thyroid Association·Quan-Yang DuhGregory Randolph
Jan 5, 2018·Endocrine Reviews·Elizabeth J de KosterDennis Vriens
Dec 20, 2017·Endocrine-related Cancer·Sergio Vargas-SalasHernán E González
Mar 18, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Amy VoraIldiko Lingvay
May 4, 2018·Frontiers in Endocrinology·Zeyad T SahliMartha A Zeiger
Aug 11, 2020·The Journal of Clinical Endocrinology and Metabolism·Mayumi EndoFadi Nabhan
Dec 27, 2017·Cancer·Mara Y RothDavid L Steward

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