PMID: 4008909Apr 1, 1985Paper

Outcome of toxic dilatation in ulcerative and Crohn's colitis

Journal of Clinical Gastroenterology
A J GreensteinA H Aufses


A review of 1,236 patients admitted to The Mount Sinai Hospital with inflammatory bowel disease between 1960 and 1979 yielded 75 cases (6%) with toxic dilatation of the colon. There were 61 cases among 613 patients (10%) with ulcerative colitis (UC), and 14 of 623 (2.3%) with Crohn's disease (CD). Fifty-nine of the 75 patients (79%) underwent surgery during their hospitalization with toxic dilatation. Twelve of the 75 patients (16%) died. Both UC and CD groups had similar mean ages at onset of colitis (32 years and 31 years, respectively) and at development of toxic dilatation (37 years); similar durations of overall disease (4.8 and 5.9 years) and of toxic dilatation prior to surgery (11 days and 13 days); and similar anatomic distributions of disease. Both UC and CD also had similar mortality rates (16% and 14%). Mean duration of presenting attack up to onset of toxic megacolon was longer in CD than in UC (62 days versus 31 days) and in unoperated versus operated cases (64 days versus 37 days), but was not significantly different between survivors and mortalities (43 days versus 39 days). Mortality rates were also unaffected by total duration of inflammatory bowel disease, first attack versus relapse (14% versus 18%), or medi...Continue Reading


Oct 20, 2011·Inflammatory Bowel Diseases·Daniel M Autenrieth, Daniel C Baumgart
Jun 1, 1994·Diseases of the Colon and Rectum·S R Binderow, S D Wexner
Nov 1, 1989·Diseases of the Colon and Rectum·C E LeijonmarckG Hellers
Feb 1, 1986·British Journal of Hospital Medicine·I J Gordon, J H Coakley
Nov 1, 2005·Diseases of the Colon and Rectum·Jeffrey L CohenStandards Practice Task Force American Society of Colon and Rectal Surgeons
Aug 11, 2007·Diseases of the Colon and Rectum·Scott StrongStandards Practice Task Force of The American Society of Colon and Rectal Surgeons
Jun 15, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Alessandro Fichera, Fabrizio Michelassi
Jun 6, 2007·Current Treatment Options in Gastroenterology·Stephen B Hanauer, Arnold Wald
Nov 1, 2007·Clinics in Colon and Rectal Surgery·Steven Mills, Michael J Stamos
Jun 7, 2003·Inflammatory Bowel Diseases·David B Sachar
Feb 19, 2008·Journal of Clinical Gastroenterology·Loren BermanKurt E Roberts
Mar 18, 2005·Acta chirurgica Iugoslavica·G BarisicD Masulovic
May 8, 2008·World Journal of Gastroenterology : WJG·John M Hwang, Madhulika G Varma
Sep 16, 1998·Lancet·K KurokiA Kuroki
Jan 10, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·P H E TeeuwenR P Bleichrodt
Aug 19, 2014·Internal Medicine·Ken NarabayashiKazuhide Higuchi
Apr 1, 1988·World Journal of Surgery·P R Hawley
Apr 14, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Valeria CriscuoliMario Cottone
Jan 5, 2016·Alimentary Pharmacology & Therapeutics·D Seah, P De Cruz
Apr 5, 2008·The Medical Clinics of North America·Francisco MarreroBret A Lashner
Nov 25, 2015·The Surgical Clinics of North America·William J Harb
Jan 20, 2012·Journal of Digestive Diseases·David B Sachar
Jun 1, 1990·American Journal of Surgery·J H RobertA J Greenstein
Apr 30, 2002·Best Practice & Research. Clinical Gastroenterology·Suryakanth GuruduJeffry A Katz
Nov 26, 2003·The American Journal of Gastroenterology·S Ian Gan, P L Beck
Mar 1, 1989·Gastroenterology Clinics of North America·S H Danovitch
Nov 24, 2011·The American Journal of Gastroenterology·Alain BittonCanadian Association of Gastroenterology Severe Ulcerative Colitis Consensus Group
Jul 6, 2004·The American Journal of Gastroenterology·Asher KornbluthPractice Parameters Committee of the American College of Gastroenterology
Mar 6, 2012·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Chang Hwan ChoiIBD Study Group of the Korean Association for the Study of Intestinal Diseases
Aug 23, 2011·Journal of Clinical Gastroenterology·Erwin-Jan M van Geenen, David B Sachar
Feb 3, 2007·Nature Clinical Practice. Gastroenterology & Hepatology·Renzo CaprilliGiovanni Latella
May 31, 2008·The American Journal of Gastroenterology·Eric I BenchimolAnne M Griffiths
Jul 1, 1992·The British Journal of Surgery·R L NgN J Mortensen
Oct 28, 2008·Dimensions of Critical Care Nursing : DCCN·Megan M Earhart
Sep 21, 2005·Digestion·Carmelo D'AmicoDavide Francesco D'Amico
Feb 10, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C AuschR Schiessel
Mar 15, 2015·Journal of Ultrasound·Fiorenzo BottiEttore Contessini Avesani
Dec 10, 2013·Diseases of the Colon and Rectum·Howard RossStandards Practice Task Force of the American Society of Colon and Rectal Surgeons
Dec 1, 1986·Diseases of the Colon and Rectum·J HeppellD Bernard
Mar 17, 2020·Techniques in Coloproctology·G PellinoItalian Society of Colorectal Surgery SICCR
Aug 14, 2010·Diseases of the Colon and Rectum·Lei LianBo Shen
Nov 12, 2016·World Journal of Gastroenterology : WJG·James Wt TohChristopher J Young
Oct 8, 2015·Diseases of the Colon and Rectum·Scott StrongClinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons
Jul 16, 2019·La Radiologia medica·Sara GuerriVittorio Miele
Jun 18, 2020·Clinical and Experimental Gastroenterology·Jiten DesaiRajkumar Doshi
Nov 4, 2019·The Surgical Clinics of North America·Sean Flynn, Samuel Eisenstein
Nov 4, 2015·Radiologic Clinics of North America·Mark E Baker
Nov 16, 2020·Radiography·E EghbaliH Hosseinifard
May 11, 2021·World Journal of Emergency Surgery : WJES·Belinda De SimoneFausto Catena
Apr 15, 2021·Diseases of the Colon and Rectum·Stefan D HolubarPrepared on behalf of the Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons.

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.