Outcome of transarterial chemoembolization-based multi-modal treatment in patients with unresectable hepatocellular carcinoma

World Journal of Gastroenterology : WJG
Do Seon SongSeung Kew Yoon

Abstract

To investigate the efficacy and safety of transarterial chemoembolization (TACE)-based multimodal treatment in patients with large hepatocellular carcinoma (HCC). A total of 146 consecutive patients were included in the analysis, and their medical records and radiological data were reviewed retrospectively. In total, 119 patients received TACE-based multi-modal treatments, and the remaining 27 received conservative management. Overall survival (P<0.001) and objective tumor response (P=0.003) were significantly better in the treatment group than in the conservative group. After subgroup analysis, survival benefits were observed not only in the multi-modal treatment group compared with the TACE-only group (P=0.002) but also in the surgical treatment group compared with the loco-regional treatment-only group (P<0.001). Multivariate analysis identified tumor stage (P<0.001) and tumor type (P=0.009) as two independent pre-treatment factors for survival. After adjusting for significant pre-treatment prognostic factors, objective response (P<0.001), surgical treatment (P=0.009), and multi-modal treatment (P=0.002) were identified as independent post-treatment prognostic factors. TACE-based multi-modal treatments were safe and more ben...Continue Reading

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Citations

Jun 9, 2016·World Journal of Gastroenterology : WJG·Peng-Hui HuMeng Xu
Mar 14, 2018·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·H AbdellaA El Dorry
Feb 13, 2021·International Journal of Nanomedicine·Wen-Sheng TzengYow-Ling Shiue
Mar 12, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Zhaonan LiZaoqu Liu

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