Outcome of treatment of mooren ulcer with topical cyclosporine a 2%

Cornea
Radhika TandonJeewan S Titiyal

Abstract

To study the clinical outcome of treatment of Mooren ulcer with topical cyclosporine A (CsA) 2% as an adjunct to standard therapy. Seventeen eyes of 15 patients with Mooren ulcer treated with CsA 2% eyedrops were included. Five eyes had undergone a full-thickness patch graft for perforation and were started on topical CsA therapy after surgery. Topical CsA had been started in the other 12 eyes as an adjunct to standard medical therapy after treatment failure. Clinical efficacy was evaluated on the basis of reduction in lesion size, healing of the epithelial defect, visual recovery, and recurrence rate. In 12 eyes to which topical CsA had been given as an adjunct therapy, the ulcers had resolved completely with various degrees of vascularization. The mean healing time including complete epithelization was 34.4 +/- 13.1 days (range, 14-56 days). During the follow-up period of 12 months, recurrence had been observed in 1 patient. No recurrence of the ulcer was seen in the 5 eyes that were started on topical CsA therapy after tectonic keratoplasty. A significant (P = 0.004) improvement was seen in the mean best-corrected visual acuity from the pretreatment values at 12 months. No adverse effects attributable to CsA were observed. T...Continue Reading

References

Nov 1, 1991·Ophthalmology·J H Bleik, K F Tabbara
Dec 15, 1990·American Journal of Ophthalmology·A G SecchiA Leonardi
Jan 1, 1987·The British Journal of Ophthalmology·J C Hill, P Potter
Jun 1, 1987·The British Journal of Ophthalmology·D Wakefield, L P Robinson
Jan 1, 1996·International Ophthalmology Clinics·C Y Chow, C S Foster
Jan 1, 1996·International Ophthalmology Clinics·J C Abad, C S Foster
Oct 26, 2000·The British Journal of Ophthalmology·J ChenY Lin
Feb 23, 2002·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Julian ThengKwok-Wai La
Jan 3, 2006·American Journal of Ophthalmology·Serge DoanThanh Hoang-Xuan
Jan 17, 2007·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Adil Kiliç, Bülent Gürler

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Citations

Apr 24, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Rajesh SinhaRasik B Vajpayee
Sep 21, 2013·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·J S SteinbergK U Loeffler
Feb 22, 2016·Archivos de la Sociedad Española de Oftalmología·F VilaplanaJ Barraquer
Nov 29, 2011·Survey of Ophthalmology·Vishal JhanjiRasik B Vajpayee
Jul 28, 2016·The British Journal of Ophthalmology·Damien GuindoletEric E Gabison
Dec 8, 2017·BMC Ophthalmology·Vesa AaltonenMohammad Al-Juhaish
Jan 24, 2014·The Cochrane Database of Systematic Reviews·Mahmoud B AlhassanIdris O Agbabiaka
Mar 4, 2021·Survey of Ophthalmology·Yogita GuptaRadhika Tandon

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