Outcome prediction for patients with renal cell carcinoma

Seminars in Diagnostic Pathology
Christine M LohseJohn C Cheville

Abstract

Outcome assessment for renal cell carcinoma is somewhat controversial. Despite numerous studies, a very limited variety of features have been recognized as having prognostic significance in clinical practice. In this review, tumor features considered to be of importance in outcome prediction for surgically treated patients with the 3 most commonly encountered morphotypes of renal cell carcinoma (clear cell, papillary, and chromophobe renal cell carcinoma) are evaluated. In particular, we have focused upon histologic subtype, sarcomatoid and rhabdoid differentiation, TNM staging, primary tumor size, tumor grade, and the presence of histologic coagulative tumor necrosis. We have also examined the importance of these prognostic features in a variety of postoperative or outcome prediction models developed by several institutions.

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Citations

Nov 28, 2015·Surgical Pathology Clinics·Michelle S HirschPaola Dal Cin
Mar 25, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sounak GuptaWilliam R Sukov
Oct 4, 2017·Oncotarget·Meijun DuLiang Wang
Dec 20, 2018·Histopathology·Sean R WilliamsonLiang Cheng
Dec 20, 2018·Histopathology·Brett DelahuntHemamali Samaratunga
Aug 29, 2020·Kidney Research and Clinical Practice·Francesca AmbrosiAntonia D'Errico
Oct 31, 2020·Pathology·Brett DelahuntLars Egevad

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