Outcome prediction in patients at high risk for coronary artery disease: comparison between 99mTc tetrofosmin and 99mTc sestamibi

Radiology
Salvador Borges-NetoDavid Whellan

Abstract

To determine if there was any difference in the ability of physicians to predict prognosis with technetium 99m ((99m)Tc) sestamibi or (99m)Tc tetrofosmin in a large consecutive series of patients at high risk for coronary artery disease who underwent coronary angiography. This study included 1,818 consecutive patients who underwent a rest and stress single photon emission computed tomographic (SPECT) examination with either (99m)Tc sestamibi (n = 915) or (99m)Tc tetrofosmin (n = 903) and cardiac catheterization. A clinical index was generated and consisted of clinical and demographic variables. Information concerning death, cardiovascular death, and nonfatal myocardial infarction was 93% complete during the 1.5-year study period. Cox proportional hazards models were generated to help determine the incremental contribution of SPECT sum stress score (SSS) and the imaging agent variable to the clinical index. Exercise was used for stress testing in 473 (52%) patients who received (99m)Tc tetrofosmin and 519 (57%) patients who received (99m)Tc sestamibi (P =.06). Cardiovascular death or myocardial infarction occurred in 130 patients. Resulting P values for chi(2) differences between models for the end points of (a) death from any c...Continue Reading

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Citations

Nov 18, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Ichiro MatsunariNorihisa Tonami
Jun 10, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Abdou ElhendyDon Poldermans
Jun 6, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Michael SalernoSalvador Borges-Neto
Aug 10, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Hendrik J BoitenArend F L Schinkel
Jun 7, 2007·The British Journal of Radiology·M HawkinsK M Bradley
Jan 16, 2007·Journal of the American College of Cardiology·Louise D MetzKirsten E Fleischmann
Jul 14, 2012·JACC. Cardiovascular Imaging·Afshin Farzaneh-FarSalvador Borges-Neto
Jan 27, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Paul L HessSalvador Borges-Neto
May 20, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Afshin Farzaneh-FarSalvador Borges-Neto
Aug 9, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Marat FudimSalvador Borges-Neto
May 4, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Howard Weinstein, Richard Steingart

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