Outcome predictors of radical prostatectomy followed by adjuvant androgen deprivation in patients with clinical high risk prostate cancer and pT3 surgical margin positive disease

The Journal of Urology
Martin SpahnEuropean Multicenter Prostate Cancer Clinical and Translational Research Group

Abstract

Patients with high risk prostate cancer with pT3 tumor and positive surgical margins have a high risk of biochemical failure after radical prostatectomy and adjuvant androgen deprivation therapy. Predictors of cancer related death in this patient group are necessary. We performed subset analysis of a prospective trial including 550 consecutive patients with preoperative high risk prostate cancer (prostate specific antigen greater than 20 ng/ml ± cT3/4 ± biopsy Gleason 8-10). Men who underwent radical prostatectomy and received continuous adjuvant androgen deprivation therapy for pT3a/b N0-1 positive surgical margin disease were included in the analysis, and none of the patients received neoadjuvant androgen deprivation therapy or adjuvant radiation therapy. Overall 173 of 550 patients (31.5%) with a median followup of 67 months met the study inclusion criteria. For these men the estimated 8-year prostate cancer specific and overall survival rates were 86.3% and 77.0%, respectively. Tumor stage and positive surgical margin at the bladder neck were independent predictors of prostate cancer specific survival and overall survival, and were used to substratify cases. Those with pT3b disease with positive surgical margins at the blad...Continue Reading

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Citations

May 14, 2014·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·L CormierUNKNOWN les membres du sous-comité « prostate » du CCAFU
Sep 20, 2016·Clinical Genitourinary Cancer·Valerio VagnoniRiccardo Schiavina
Feb 22, 2017·BJU International·Martin SpahnUNKNOWN European Multicenter Prostate Cancer Clinical and Translational Research Group (EMPAcT)
Jun 1, 2019·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Saum GhodoussipourAndre Luis de Castro Abreu
Nov 7, 2017·BJU International·Kelly Stratton
May 16, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·R Jeffrey KarnesEdward M Schaeffer
May 5, 2021·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·R Tambwe KayomboS Larré

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