PMID: 9426027Jan 13, 1998Paper

Outcome with calcium channel antagonists after myocardial infarction: a community-based study

Journal of the American College of Cardiology
J W LeitchR Heller

Abstract

We sought to estimate the risk of death and recurrent myocardial infarction associated with the use of calcium antagonists after myocardial infarction in a population-based cohort study. Calcium antagonists are commonly prescribed after myocardial infarction, but their long-term effects are not well established. Patients 25 to 69 years old with a suspected myocardial infarction were identified and followed up through a community-based register of myocardial infarction and cardiac death (part of the World Health Organization Monitoring Trends and Determinants in Cardiovascular Disease [MONICA] Project in Newcastle, Australia). Data were collected by review of medical records, in-hospital interview and review of death certificates. From 1989 to 1993, 3,982 patients with a nonfatal suspected myocardial infarction were enrolled in the study. At hospital discharge, 1,001 patients were treated with beta-adrenergic blocking agents, 923 with calcium antagonists, 711 with both beta-blockers and calcium antagonists and 1,346 with neither drug. Compared with patients given beta-blockers, patients given calcium antagonists were more likely to suffer myocardial infarction or cardiac death (adjusted relative risk [RR] 1.4, 95% confidence int...Continue Reading

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Citations

Jun 10, 2000·Journal of Clinical Pharmacy and Therapeutics·K S McNamaraW T Friesen
Oct 3, 2015·The International Journal of Biochemistry & Cell Biology·Charumathi PushparajCarles Cantí
May 26, 1999·Current Problems in Cardiology·M FreherM Gheorgiade
May 17, 2006·Journal of Cardiovascular Pharmacology and Therapeutics·Naranjan S DhallaRamesh K Goyal
Apr 30, 2003·Journal of Cardiovascular Pharmacology·Philip B AdamsonPeter J Schwartz

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