Outcomes After Decompression of the Right Ventricle in Infants With Pulmonary Atresia With Intact Ventricular Septum Are Associated With Degree of Tricuspid Regurgitation: Results From the Congenital Catheterization Research Collaborative

Circulation. Cardiovascular Interventions
Christopher J PetitBryan H Goldstein

Abstract

Outcomes after right ventricle (RV) decompression in infants with pulmonary atresia with intact ventricular septum vary widely. Descriptions of outcomes are limited to small single-center studies. Neonates undergoing RV decompression for pulmonary atresia with intact ventricular septum were included from 4 pediatric centers. Primary end point was reintervention post-RV decompression; secondary end points included circulation type at latest follow-up. Ninety-nine patients (71 with pulmonary atresia with intact ventricular septum and 28 with virtual atresia) underwent RV decompression at median 3 (25th-75th, 2-5) days of age. Seventy-one patients (72%) underwent at least 1 reintervention after decompression. Median duration of follow-up was 3 years (range, 1-10). Freedom from reintervention was 51% at 1 month and 23% at 3 years. In multivariable analysis, reintervention was associated with virtual atresia (hazard ratio [HR], 0.51; 95% confidence interval [CI], 0.28-091;P=0.027), smaller RV length (HR, 0.94; 95% CI, 0.89-0.99;P=0.027), and ≤mild tricuspid regurgitation (TR; HR, 3.58; 95% CI, 2.04-6.30;P<0.001). Patients undergoing surgical shunt or ductal stent were less likely to have virtual atresia (HR, 0.36; 95% CI, 0.15-0.85;...Continue Reading

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Citations

Dec 10, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Holly Bauser-HeatonChristopher J Petit
Apr 19, 2019·Circulation. Cardiovascular Interventions·Bryan H GoldsteinAndrew C Glatz
May 6, 2020·Pediatric Cardiology·Bassel Mohammad NijresJoseph J Vettukattil
Feb 23, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Athar M QureshiChristopher J Petit
Jan 5, 2021·Pediatric Cardiology·Bryan H GoldsteinAndrew C Glatz
Mar 18, 2021·Cardiology in the Young·Joelle A PettusUNKNOWN Congenital Cardiac Research Collaborative
Apr 18, 2021·The Annals of Thoracic Surgery·Yuichiro SugitaniYoshie Ochiai

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