Outcomes After Kidney injury in Surgery (OAKS): protocol for a multicentre, observational cohort study of acute kidney injury following major gastrointestinal and liver surgery

BMJ Open
STARSurg Collaborative

Abstract

Acute kidney injury (AKI) is associated with increased morbidity and mortality following cardiac surgery. Data focusing on the patterns of AKI following major gastrointestinal surgery could inform quality improvement projects and clinical trials, but there is a lack of reliable evidence. This multicentre study aims to determine the incidence and impact of AKI following major gastrointestinal and liver surgery. This prospective, collaborative, multicentre cohort study will include consecutive adults undergoing gastrointestinal resection, liver resection or reversal of ileostomy or colostomy. Open and laparoscopic procedures in elective and emergency patients will be included in the study. The primary end point will be the incidence of AKI within 7 days of surgery, identified using an adaptation of the National Algorithm for Detecting Acute Kidney Injury, which is based on the Kidney Disease Improving Global Outcomes (KDIGO) AKI guidelines. Secondary outcomes will include persistent renal dysfunction at discharge and 1 year postoperatively. The 30-day adverse event rate will be measured using the Clavien-Dindo scale. Data on factors that may predispose to the development of AKI will be collected to identify variables associated w...Continue Reading

References

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Citations

Mar 7, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·F C HongR R W Brady
Jan 19, 2019·Anaesthesia·T M DrakeA Borakati
Aug 9, 2019·Interactive Cardiovascular and Thoracic Surgery·Vinci NarukaAman S Coonar
Aug 19, 2017·Current Opinion in Critical Care·Suvi T Vaara, Rinaldo Bellomo
Dec 21, 2019·Annals of the Royal College of Surgeons of England·R M KwasnickiM D Gardiner
Jun 15, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ziad A MassyCarmine Zoccali
Sep 27, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·UNKNOWN 2017 European Society of Coloproctology (ESCP) collaborating group
Jan 4, 2020·International Journal of Surgery Protocols·Brenig Llwyd GwilymDavid Charles Bosanquet
Dec 19, 2019·International Journal of Surgery Protocols·UNKNOWN National Research Collaborative Meeting 2017 Organising Committee, UNKNOWN West Midlands Research Collaborative

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Software Mentioned

REDCap
R
STARSurg
OAKS
R Foundation Statistical Programming
Research Electronic Data Capture ( REDCap )

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