Outcomes After Surgery and Radiotherapy for Papillary Tumor of the Pineal Region

World Neurosurgery
Mark A EdsonJing Li

Abstract

Papillary tumor of the pineal region (PTPR) is a rare neuroectodermal tumor that was first described in 2003 and formally codified by the World Health Organization in 2007. Limited reports suggest surgical resection is the mainstay of treatment; however, the role of multimodality therapy is not well defined. We evaluated our institutional experience in the treatment of PTPR. A retrospective review of 8 patients with pathologically confirmed PTPR diagnosed between 1999 and 2013 was performed. The median age at diagnosis was 37 years (range, 25-56 years). After a median follow-up period of 60 months (range, 10-170 months), 7 of 8 patients were still living. All patients underwent maximum safe surgical resection; 5 received adjuvant radiation (63%). Overall and progression-free survival 5 years after diagnosis were 100% and 51%, respectively. Progression-free survival 5 years after completion of adjuvant radiotherapy was 64%. Crude recurrence rates for patients receiving adjuvant radiotherapy (n = 5) and patients not receiving adjuvant radiotherapy (n = 3) were 20% and 67%, respectively. Crude recurrence rate after gross total resection (GTR) and no adjuvant radiotherapy (n = 2) was 100% versus 0% when adjuvant radiotherapy was ad...Continue Reading

References

Apr 28, 2006·Neuropathology and Applied Neurobiology·M HasselblattW Paulus
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
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May 25, 2012·Brain Tumor Pathology·Juliana MagalhãesFausto J Rodriguez
Mar 1, 2013·Stereotactic and Functional Neurosurgery·Paul RiisWolfgang Börm

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Citations

Jan 18, 2018·Translational Neuroscience·Zbigniew KotwicaPiotr Kasprzak
Apr 17, 2019·Neurosurgery·Vitor Nagai YamakiEberval Gadelha Figueiredo
Apr 4, 2021·Cancers·Gaia FaveroRita Rezzani
Jul 17, 2021·Asian Journal of Neurosurgery·Nirav MehtaSalman Shaikh

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