Outcomes and patterns of radiation associated brain image changes after proton therapy for head and neck skull base cancers.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Grete May EngesethGary Brandon Gunn

Abstract

To characterize patterns and outcomes of brain MR image changes after proton therapy (PT) for skull base head and neck cancer (HNC). Post-treatment MRIs ≥6 months were reviewed for radiation-associated image changes (RAIC) in 127 patients. All patients had received at least a point dose of 40 Gy(RBE) to the brain. The MRIs were rigidly registered to planning CTs and RAIC lesions were contoured both on T1 weighted (post-contrast) and T2 weighted sequences, and dose-volume parameters extracted. Probability of RAIC was calculated using multistate survival analysis. Univariate/multivariate analyses were performed using Cox Regression. Recursive partitioning analysis was used to investigate dose-volume correlates of RAIC development. 17.3% developed RAIC. All RAIC events were asymptomatic and occurred in the temporal lobe (14), frontal lobe (6) and cerebellum (2). The median volume of the contrast enhanced RAIC lesion was 0.5 cc at their maximum size. The RAIC resolved or improved in 45.5% of the patients and were stable or progressed in 36.4%. The 3-year actuarial rate of developing RAIC was 14.3%. RAIC was observed in 63% of patients when V67 Gy(RBE) of the brain ≥0.17 cc. Small RAIC lesions after PT occurred in 17.3% of the patie...Continue Reading

References

Dec 19, 2009·Radiology·Yi-Xiang J WangAnil T Ahuja
Mar 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Yaacov Richard LawrenceAdam P Dicker
Feb 22, 2012·International Journal of Radiation Oncology, Biology, Physics·Berrin PehlivanEugen B Hug
Aug 4, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sheng-Fa SuTai-Xiang Lu
Sep 15, 2012·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Ritu ShahJoel K Curé
Feb 19, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Gazanfar RahmathullaRobert J Weil
Feb 1, 2015·International Journal of Radiation Oncology, Biology, Physics·Mark W McDonaldCynthia S J Calley
Apr 17, 2016·International Journal of Radiation Oncology, Biology, Physics·Roi DaganWilliam M Mendenhall
Jul 6, 2019·International Journal of Radiation Oncology, Biology, Physics·Anne W LeeJoseph T Wee
Sep 30, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Maximilian NiyaziHelen A Shih

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Jul 21, 2021·Life Sciences in Space Research·Walter TinganelliMarco Durante

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