Outcomes and resource use of non-small cell lung cancer (NSCLC) patients treated with first-line platinum-based chemotherapy across Europe: FRAME prospective observational study

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Denis Moro-SibilotPhilipp A Schnabel

Abstract

FRAME was a prospective observational study that captured real-world data on patients with advanced or metastatic non-small cell lung cancer (NSCLC) receiving platinum-based chemotherapies as first-line treatment (FLT) across Europe. As previously reported, most patients observed in the study had initiated FLT with either pemetrexed, gemcitabine, vinorelbine or taxanes in combination with a platinum. Baseline patient and disease characteristics including age, performance status, and histology varied (all p<0.01) across cohorts. Consenting adult patients initiating FLT for advanced or metastatic NSCLC with platinum-based chemotherapy, with or without a targeted agent, entered the study between April 2009 and February 2011. The choice of FLT was left to physicians' discretion per routine clinical practice. The primary objective was to evaluate overall survival (OS) across platinum-based doublet chemotherapy cohorts and key secondary objectives included the evaluation of OS in patients with different histological subtypes of NSCLC. Survival outcomes were assessed using Kaplan-Meier analysis, and unadjusted estimates are presented. Median OS in months was 10.3 across cohorts (n=1524), 10.7 for pemetrexed (n=569), 10.0 for gemcitabi...Continue Reading

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Citations

Feb 15, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Liza C Villaruz, Mark A Socinski
Jan 19, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Egbert SmitPhilipp A Schnabel
Jan 23, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Denis Moro-SibilotPhilipp A Schnabel
Aug 19, 2016·Anti-cancer Drugs·Kang QiXiangYang Chu
Jun 22, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P N AguiarG L Lopes
Mar 28, 2019·Cancer Biotherapy & Radiopharmaceuticals·Senhua SangJianwei Shan
Nov 1, 2016·Lung Cancer Management·Pedro AguiarGilberto L Lopes
Apr 18, 2020·Clinical Pharmacology and Therapeutics·Michael HappichUNKNOWN IMI GetReal Work Package 1

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