Abstract
Heart transplantation (HT) is the treatment of choice in children with end-stage cardiomyopathy. Several clinical, morphological, demographic, donor and recipient transplant factors have been demonstrated to affect survival in those patients following listing for HT and following HT. We aim to report our single institution results of HT in children with cardiomyopathy, and explore variables affecting survival and the need for heart retransplantation (RHT). Between 1988 and 2013, 125 children with cardiomyopathy underwent HT. Competing risks analysis modelled events after HT (RHT, death without RHT). Multivariable regression analysis examined risk factors affecting outcomes and parametric models were used to compare survival between diverse groups of patients. There were 62 males (50%). Cardiomyopathy types were dilated (n = 104, 83%), restrictive (n = 10, 8%), chemotherapy-induced (n = 7, 6%), and other (n = 4, 3%). Median age at listing was 6.9 years and median age at HT was 7.0 years with median waiting list duration of 29 days. Thirty-four patients were infants <1 year. At time of HT, 106 patients (85%) were at United Network for Organ Sharing status-1, 25 (20%) were ventilated and 17 (14%) had mechanical circulatory support...Continue Reading
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