Outcomes Associated With 3 Treatment Schedules of High-Dose-Rate Brachytherapy Monotherapy for Favorable-Risk Prostate Cancer

International Journal of Radiation Oncology, Biology, Physics
Maha Saada JawadDaniel Krauss

Abstract

We report the outcomes associated with 3 high-dose-rate (HDR) brachytherapy regimens used as monotherapy for favorable-risk prostate cancer. Four hundred ninety-four patients with stage ≤T2b prostate cancer, Gleason score ≤7, and prostate-specific antigen levels ≤15 ng/mL underwent HDR brachytherapy as monotherapy. Of those, 319 received 38 Gy in 4 fractions, 79 received 24 Gy in 2 fractions, and 96 received 27 Gy in 2 fractions. Acute and chronic genitourinary (GU) and gastrointestinal (GI) toxicities were defined as side effects occurring ≤6 and >6 months, respectively, after radiation therapy (RT) and were graded according to the Common Terminology Criteria for Adverse Events version 3.0. The time to toxicity was calculated from the date of RT completion. Variables were analyzed with χ(2) test. P values <.05 were considered significant. The median overall follow-up time was 4 years (range, 5.5, 3.5, and 2.5 years for 38 Gy, 24 Gy, and 27 Gy, respectively, P<.001). Acute and chronic grade ≥2 GU and GI toxicity profiles were similar among groups. Acceptable rates of grade 2 GU toxicities were seen with overall acute/chronic frequency/urgency, dysuria, retention, incontinence, and hematuria rates of 14%/20%, 6%/7%, 7%/4%, 1.5%/...Continue Reading

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Citations

Mar 15, 2016·International Journal of Radiation Oncology, Biology, Physics·Paul L Nguyen, Jay P Ciezki
Jun 18, 2017·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Georgios ChatzikonstantinouNikolaos Tselis
Mar 7, 2020·Japanese Journal of Clinical Oncology·Jun Itami
Nov 27, 2020·Clinical and Translational Radiation Oncology·Jonathan MohajerAlison Tree
Jan 20, 2021·Brachytherapy·Gustavo Arruda VianiLigia Issa De Fendi
Feb 23, 2021·Brachytherapy·Kevin Martell, Marisa A Kollmeier
Jul 18, 2021·BJU International·Sophia C Kamran, Anthony L Zietman
Mar 28, 2017·Clinical Oncology : a Journal of the Royal College of Radiologists·N TselisG Chatzikonstantinou

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