Outcomes associated with bacteremia in the setting of methicillin-resistant Staphylococcus aureus pneumonia: a retrospective cohort study

Critical Care : the Official Journal of the Critical Care Forum
Andrew F ShorrMarin H Kollef

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) remains an important pathogen in pneumonia. Bacteremia may secondarily complicate MRSA pneumonia. The epidemiology and outcomes associated with bacteremia in the setting of MRSA pneumonia are unknown. We sought to describe the prevalence of bacteremia in MRSA pneumonia and its impact on hospital mortality and length of stay (LOS). We conducted a single-center retrospective cohort study (2008-2013) including adult patients hospitalized with pneumonia caused by MRSA. We defined pneumonia based on clinical criteria and all cases were culture confirmed. MRSA bacteremia was identified based on positive blood cultures. Pneumonia was categorized as either community-onset (CO, occurring at presentation or within 2 days of admission) or hospital-onset (HO, occurring > 2 days after admission). We compared bacteremic and non-bacteremic groups with respect to their demographic and clinical characteristics and outcomes. A logistic regression and a generalized linear model (GLM) were constructed to examine the impact of bacteremia on hospital mortality and post-pneumonia onset LOS, respectively. Among the 765 patients with MRSA pneumonia (33.1% CO), 93 (12.2%) had concurrent bacteremia (37.6...Continue Reading

References

Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Nov 1, 1994·Journal of Clinical Epidemiology·M CharlsonJ Gold
Oct 8, 2009·The Medical Journal of Australia·John D TurnidgeUNKNOWN Australia New Zealand Cooperative on Outcomes in Staphylococcal Sepsis
Aug 12, 2010·JAMA : the Journal of the American Medical Association·Alexander J KallenUNKNOWN Active Bacterial Core surveillance (ABCs) MRSA Investigators of the Emerging Infections Program
Nov 3, 2010·Journal of Critical Care·Matthew P SchreiberAndrew F Shorr
Feb 18, 2011·Critical Care : the Official Journal of the Critical Care Forum·Mònica MagretUNKNOWN EU-VAP/CAP Study Group
Jun 7, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pierre TattevinBinh An Diep
Jun 19, 2012·Expert Review of Anti-infective Therapy·Matteo BassettiPaolo Pelosi
Mar 26, 2013·Current Opinion in Pulmonary Medicine·François BarbierLila Bouadma
Dec 18, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Keith A Rodvold, Kevin W McConeghy
Mar 4, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J ChastreT Welte
Jan 21, 2015·International Journal of Antimicrobial Agents·Robert MastertonAntoni Torres

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Citations

Apr 23, 2016·The Journal of Perinatal & Neonatal Nursing·Jan M Kriebs
Jan 6, 2016·Antimicrobial Agents and Chemotherapy·Kimberly C ClaeysMichael J Rybak
Mar 19, 2016·Current Opinion in Pulmonary Medicine·Markus MaeurerAlimuddin Zumla
May 2, 2018·Antimicrobial Resistance and Infection Control·Nichola R NaylorJulie V Robotham
Apr 16, 2021·Therapeutic Advances in Infectious Disease·Alexander H FlanneryPeter E Morris

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