Outcomes associated with immune-related adverse events in metastatic non-small cell lung cancer treated with nivolumab: a pooled exploratory analysis from a global cohort.

Cancer Immunology, Immunotherapy : CII
Abdul Rafeh NaqashPaul R Walker

Abstract

Immune-related adverse events (irAEs) comprise a distinct spectrum of auto-inflammatory manifestations triggered due to immune checkpoint inhibitors (ICI). Current data on the association of irAEs with outcomes in NSCLC treated with nivolumab are limited. We pooled data from 531 metastatic NSCLC patients from five centers treated with nivolumab after failing platinum-based chemotherapy. The primary objective was to investigate the relationship between irAEs with clinical benefit to nivolumab as well as to elucidate patterns of irAE-related ICI discontinuations and their impact on survival. 33.0% (173/531) of patients treated with nivolumab were noted to have an irAE. Patients with irAEs had a significantly longer median PFS [6.1 vs. 3.1 months, HR 0.68 95% CI (0.55-0.85); p = 0.001] and OS [14.9 vs. 7.4 months, HR 0.66 95% CI (0.52-0.82); p < 0.001)] compared to those without irAEs. In multivariate analysis, the presence of irAEs showed a significantly better PFS [HR 0.69, 95% CI (0.55-0.87); p = 0.002] and a trend for better OS [HR 0.62, 95% CI (0.55-1.03); p = 0.057]. Patients with permanent ICI discontinuation secondary to index irAE had a significantly shorter median PFS [2.3 vs. 6.6 months, HR 1.74 95% CI (1.06-2.80); p = ...Continue Reading

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Citations

Jul 30, 2020·Expert Review of Anticancer Therapy·Yousef R BadranMichael Dougan
Dec 3, 2020·International Journal of Molecular Sciences·Valentina TateoMaria Abbondanza Pantaleo
Mar 26, 2021·OncoTargets and Therapy·Taichi MatsubaraTatsuro Okamoto
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Jun 17, 2021·BMJ Supportive & Palliative Care·Ana Filipa Palma Dos ReisAndrew Wilcock
Jul 5, 2021·Journal of Experimental & Clinical Cancer Research : CR·Xinyi LiuLing Dong
Jul 29, 2021·Nature Reviews. Drug Discovery·Ryan J Sullivan, Jeffrey S Weber
Oct 8, 2021·Cancer Immunology, Immunotherapy : CII·Tyler C HaddadDwight H Owen

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