Outcomes following infant listing for cardiac transplantation: the impact of strategies introduced to counteract limited donor availability

Archives of Disease in Childhood
C IrvingR Kirk

Abstract

Survival following cardiac transplantation in infancy has improved substantially. There is a growing shortage of donors, the impact of which may be offset by increase in ABO-incompatible transplants, size-mismatching and mechanical support. The authors reviewed their results and outcomes following infant listing for cardiac transplantation over 22 years. Children <12 months at time of listing for cardiac transplant in 1987-2008 were identified using the departmental cardiopulmonary transplant database. Details were obtained from databases and hospital medical records and subdivided into two eras, 1987-1997 and 1998-2008. In 1987-2008, 49 infants were listed, and 28 (57%) underwent cardiac transplantation (12 in 1987-1997 and 16 in 1998-2008). 15 patients (31%) died on the waiting list, 6 patients were delisted (5 of these because of recovery of cardiac function). There was a decrease in suitable donor offers from a mean of 36 per year in 1996-2000 to 11 per year in 2001-2006 (p=0.008). In 1998-2008, nine listed infants were on mechanical support; there were seven ABO-incompatible transplants, and all transplants were size-mismatched with donors on average 2.7 times heavier than recipients. Waiting times decreased from median 83...Continue Reading

Citations

Jan 4, 2012·British Journal of Anaesthesia·J Brierley, A Hasan
Feb 23, 2013·World Journal of Gastroenterology : WJG·Hao LuLing Lu
Jun 15, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Claire IrvingRichard Kirk
Feb 7, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Heather T HendersonKirk R Kanter
May 24, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Jacqueline M SmitsBruno Meiser
Aug 30, 2014·Internal Medicine Journal·P M A AlexanderR G Weintraub
Jun 28, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Claire A IrvingRichard Kirk
Oct 1, 2011·Seminars in Immunology·Robert A MontgomeryDaniel S Warren
Aug 13, 2014·Archives of Disease in Childhood. Fetal and Neonatal Edition·Joanna C E Wright, Adam D Barlow
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Aug 13, 2011·Current Opinion in Organ Transplantation·Lori J West
Sep 6, 2020·The Annals of Thoracic Surgery·Deborah KozikBahaaldin Alsoufi

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