Outcomes from an International Multicentre Registry of patients with acute gastrointestinal bleeding undergoing endoscopic treatment with Hemospray

Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society
Durayd AlzoubaidiRehan Haidry

Abstract

Acute Gastro-intestinal bleeding carries poor outcomes unless prompt endoscopic hemostasis is achieved. Mortality in these patients remains significant. Hemospray is a novel intervention that creates a mechanical barrier over bleeding sites. We report the largest dataset of patient outcomes after treatment with Hemospray from an international multicentre registry. Prospective data (Jan 2016 - May 2018) from 12 centres across Europe were collected. Immediate hemostasis was defined as endoscopic cessation of bleeding within 5 minutes after application of Hemospray. Re-bleeding was defined as subsequent drop in hemoglobin, hematemesis, persistent melena with hemodynamic compromise post therapy. 314 cases have been recruited worldwide (231M & 83F). Median pre-treatment Blatchford score was 11 (IQR: 8-14) and median Complete Rockall score was 7 (IQR: 6-8) for all patients. Peptic ulcer disease was the most common pathology (167/314 = 53%) and Forrest Ib the most common bleed type in PUD (100/167 = 60%). 281 patients (89.5%) achieved immediate hemostasis after successful endoscopic therapy with Hemospray. Re-bleeding occurred in 29 (10.3%) of the 281 patients who achieved immediate hemostasis. 7-day and 30-day all-cause mortality wer...Continue Reading

References

Feb 22, 2007·The American Journal of Gastroenterology·Riccardo MarmoLivio Cipolletta
Mar 19, 2008·Best Practice & Research. Clinical Gastroenterology·M E van Leerdam
Feb 9, 2012·The American Journal of Gastroenterology·Loren Laine, Dennis M Jensen
May 26, 2012·Gastrointestinal Endoscopy·Joo Ha HwangUNKNOWN Standards of Practice Committee of the American Society for Gastrointestinal Endoscopy
Jun 12, 2013·Lancet·James Y W LauFrancis K L Chan
Nov 26, 2013·The Surgical Clinics of North America·Marcie Feinman, Elliott R Haut
Jan 10, 2017·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Monica ArenaCarmelo Luigiano
Feb 25, 2017·Gastroenterology Research and Practice·Alexander F HagelMartin Raithel

❮ Previous
Next ❯

Citations

Nov 20, 2020·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Wan YipengZhu Xuan
Jun 10, 2021·Digestive Diseases and Sciences·B Nulsen, D M Jensen
Jun 17, 2021·Journal of Gastroenterology and Hepatology·Mohamed HusseinRehan Haidry
Sep 26, 2021·Scientific Reports·Christoph R WernerMartin Götz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.