Outcomes in Burn-Injured Patients Who Develop Sepsis

Journal of Burn Care & Research : Official Publication of the American Burn Association
Megan A RechMajid Afshar

Abstract

This study examines health outcomes in burn patients with sepsis. We hypothesized that burn patients with sepsis would have an increased odds risk for in-hospital death and longer intensive care unit (ICU) stays. This was a retrospective cohort of consecutive patients admitted to the burn ICU with total BSA (TBSA) ≥10% and/or inhalation injury between January 2008 and March 2015. Overall 407 burn patients were included; the case-rate for sepsis was 39.1% (n = 159); 20.1% (n = 82) patients were septic and 18.9% (n = 77) patients experienced septic shock. Patients with septic shock had the highest mortality rate (13.31% no sepsis vs 3.7% sepsis vs 49.4% septic shock, P < .01). Median 28-day ICU-free days was higher in patients without sepsis (23 days [Interquartile range (IQR) 14-27] no sepsis vs 0 days [IQR 0-10] sepsis vs 0 days [IQR 0-0] septic shock, P < .01). Sepsis (with or without shock) increased odds of in-hospital death (odds ratio 7.04, 95% confidence interval 1.93-25.7) in reference to the no sepsis group. With each incremental Sequential Organ Failure Assessment (SOFA) score or 10% TBSA increase, the odds risk for in-hospital death increased by 56 and 75%, respectively. Our study characterized outcomes in patients wi...Continue Reading

References

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Nov 9, 2012·Journal of Burn Care & Research : Official Publication of the American Burn Association·Elizabeth A Mann-SalinasCharles E Wade
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Feb 24, 2017·Journal of Burn Care & Research : Official Publication of the American Burn Association·Megan A RechMajid Afshar
Jun 14, 2017·Burns : Journal of the International Society for Burn Injuries·Stephanie NitzschkeKenneth B Christopher

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Citations

Feb 15, 2020·Nature Reviews. Disease Primers·Marc G JeschkeSarvesh Logsetty
Dec 11, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Abdulnaser AlkhalilJeffrey W Shupp
Jul 2, 2021·Antimicrobial Resistance and Infection Control·Yangmin HuHaibin Dai

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